Evidence map›Paper›PMID 36494431›Full record

ReviewEye (London, England)2023

Perspectives of diabetic retinopathy-challenges and opportunities.

Sobha Sivaprasad, Sagnik Sen, José Cunha-Vaz

Open access · greenAbstract readReview
In one paragraph

Review in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. The role and mechanism of the miR-137 regulatory axis in diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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  10. [Quantitative Assessment of Microvascular Changes in Diabetic Retinopathy and Their Association With Blood-Retinal Barrier Impairment].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Sobha SivaprasadNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK. sobha.sivaprasad@nhs.net.
Sagnik SenDepartment of Retina and Vitreous, Aravind Eye Hospital and Aravind Medical Research Foundation, Madurai, India.ORCID 0000-0001-5835-5371
José Cunha-VazAIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal.
Moorfields Eye Hospital NHS Foundation Trust · GBAssociation for Innovation and Biomedical Research on Light and Image · PT

Funding

Medical Research Council MR/P027881/1
6 · The paper itself

Abstract

Diabetic retinopathy (DR) may lead to vision-threatening complications in people living with diabetes mellitus. Decades of research have contributed to our understanding of the pathogenesis of diabetic retinopathy from non-proliferative to proliferative (PDR) stages, the occurrence of diabetic macular oedema (DMO) and response to various treatment options. Multimodal imaging has paved the way to predict the impact of peripheral lesions and optical coherence tomography-angiography is starting to provide new knowledge on diabetic macular ischaemia. Moreover, the availability of intravitreal anti-vascular endothelial growth factors has changed the treatment paradigm of DMO and PDR. Areas of research have explored mechanisms of breakdown of the blood-retinal barrier, damage to pericytes, the extent of capillary non-perfusion, leakage and progression to neovascularisation. However, knowledge gaps remain. From this perspective, we highlight the challenges and future directions of research in this field.

Indexed as

Diabetes MellitusDiabetic RetinopathyMacular EdemaBlood-Retinal BarrierFluorescein AngiographyHumansNeovascularization, PathologicTomography, Optical Coherence

Identifiers

PMID36494431
PMCPMC10366207
OpenAlexW4311018694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.