Evidence map›Paper›PMID 36494392›Full record

ArticleScientific reports2022

NLRP3 inflammasome activation in neutrophils directs early inflammatory response in murine peritonitis.

Saeko Fukui, Shoichi Fukui, Stijn Van Bruggen, Lai Shi, Casey E Sheehy, Long Chu, Denisa D Wagner

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. NLRP3 is essential for neutrophil polarization and chemotaxis in response to leukotriene B4 gradient.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis.International journal of molecular sciences · 2023
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Saeko FukuiProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Shoichi FukuiProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Stijn Van BruggenProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Lai ShiProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Casey E SheehyProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Long ChuProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Denisa D WagnerProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA. denisa.wagner@childrens.harvard.edu.
Boston Children's Hospital · USHarvard University · USVIB-KU Leuven Center for Microbiology · BE

Funding

How inflammation and thrombosis fuel disease and aging: Focus on NETsR35HL135765 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI WAGNER, DENISA D · 2017 to 2023
$6.2M
NHLBI NIH HHS R35 HL135765NIH HHS R35 HL135765
6 · The paper itself

Abstract

NLR family pyrin domain containing 3 (NLRP3) inflammasome mediates caspase-1-dependent processing of inflammatory cytokines such as IL-1β, an essential endothelial activator, and contributes to the pathology of inflammatory diseases. To evaluate the role of NLRP3 in neutrophils in endothelial activation, which is still elusive, we used the thioglycollate-induced peritonitis model characterized by an early neutrophil influx, on Nlrp3

Indexed as

NLR Family, Pyrin Domain-Containing 3 ProteinPeritonitisAnimalsCaspase 1Endothelial CellsInflammasomesInterleukin-1betaMiceMice, Inbred C57BLNeutrophilsCaspase 1InflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouse

Identifiers

PMID36494392
PMCPMC9734191
OpenAlexW4311672497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.