Evidence map›Paper›PMID 36494250›Full record

ArticleClinical oncology (Royal College of Radiologists (Great Britain))2023

Impact of Treatment Modality on Quality of Life Among Uterine Cancer Survivors.

A K Yoder, D S Lakomy, J Wu, L M Andring, B Fellman, L E Colbert, A Jhingran, A H Klopp, P Soliman, S K Peterson and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oncology (Royal College of Radiologists (Great Britain)), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Endometrial cancer therapy in 2026.Current opinion in obstetrics & gynecology · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

A K YoderDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
D S LakomyDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Dartmouth College Geisel School of Medicine, Hanover, NH, USA.
J WuDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas School of Public Health, Houston, TX, USA.
L M AndringDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
B FellmanDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
L E ColbertDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
A JhingranDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
A H KloppDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
P SolimanDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
S K PetersonDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
L L LinDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: LLLin@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

aimsOur understanding of the impact of adjuvant therapy on longitudinal quality of life (QoL) following surgery for patients with uterine cancer is limited. The purpose of this study was to compare QoL in patients who have undergone surgery with or without radiation therapy for uterine cancer. MATERIALS AND

methodsThis was a cross-sectional cohort study that examined women treated for uterine cancer at MD Anderson Cancer Center from 2006 to 2017. Participants included those who underwent hysterectomy/bilateral salphingo-oophorectomy alone, with brachytherapy or external beam radiation therapy (EBRT). A non-cancer cohort of women who underwent a hysterectomy/bilateral salphingo-oophorectomy for benign indications was also identified (non-CA). To compare QoL we used the Functional Assessment of Cancer Therapy - Endometrial survey (FACT-En), a validated survey used to assess QoL. The survey has five subscales: physical, social, emotional, functional and an endometrial cancer-specific subscale. Cohorts were compared using ANOVA tests.

resultsIn total, 309 women responded to the questionnaire (hysterectomy/bilateral salphingo-oophorectomy 64, brachytherapy 77, EBRT 96, non-CA 72). The median time from surgery to survey completion was 6.7 years. The mean total FACT-En score for the entire cohort was 144 [standard deviation 22]. Overall QoL was different between cohorts, with the EBRT cohort reporting the lowest QoL (mean 139.4 [21.6]) and the brachytherapy cohort the highest (150.6 [18.2], P = 0.006). Among patients who had undergone cancer treatment, the EBRT cohort reported the worst endometrial-specific QoL (53.5 [8.6]), while again the brachytherapy group reported the highest score (57.5 [6.1], P = 0.007).

conclusionsQoL differences in women who have undergone different treatments for uterine cancer may persist years after treatment. In women with endometrial cancer who require adjuvant therapy, brachytherapy does not appear to have any long-term detriments on QoL.

Indexed as

BrachytherapyCancer SurvivorsEndometrial NeoplasmsUterine NeoplasmsCross-Sectional StudiesFemaleHumansNeoplasm StagingQuality of LifeRadiotherapy, AdjuvantBrachytherapygynaecological cancerquality of liferadiationsurgeryuterine cancer

Identifiers

PMID36494250
PMCPMC9904419
OpenAlexW4310798218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.