SynthesisJournal of dairy science2023
A meta-analysis of effects of 3-nitrooxypropanol on methane production, yield, and intensity in dairy cattle.
Synthesis in Journal of dairy science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 126 citations in OpenAlex.
- Feed additives as frontline tools in mitigating greenhouse gas emissions from agricultural animals.Tropical animal health and production · 2026Review
- Effects of a low dose of 3-nitrooxypropanol and a combination of direct-fed microbials on methane emission, oral swab bacterial community, and performance in dairy cows.Journal of animal science and biotechnology · 2026Article
- Nitro- and nitrooxy-organic inhibitors of methanogenesis: revealing knowledge gaps and alternate ways in bovine rumen microbiome metabolism.Applied and environmental microbiology · 2026Article
- Nutritional Strategies for Methane, Nitrogen, and Phosphorus Mitigation in Ruminants: Mechanisms, Applications, and Regional Adaptations.Microorganisms · 2026Review
- Near-complete inhibition of rumen methanogenesis via microbial and enzymatic modulation using a low dose of Asparagopsis taxiformis combined with 3-nitrooxypropanol.Journal of animal science and biotechnology · 2026Article
- Article
- High-dose phytosterols supplementation improves lactation performance, modulates rumen microbiota, and reduces methane emission intensity in mid-lactation Holstein dairy cows.Veterinary world · 2026Article
- Global research landscape and transfer-oriented synthesis of diet-based enteric methane mitigation in ruminants (2005-2025): A bibliometric and implementation-focused review.Veterinary world · 2026Article
- Breed-specific microbiomes drive differential responses to 3-nitrooxypropanol andJDS communications · 2026Article
- Effects of coenzyme M and methyl-coenzyme M on the efficacy of inhibitors of methanogenesis in rumen cultures.Scientific reports · 2026Article
- Impact of methane-mitigating concentrate feed on milk production, composition, and udder health in Holstein cows.Food science of animal resources · 2026Article
- Genetic variation in cows' response to methane-mitigating feed additives.JDS communications · 2026Article
- Article
- Advancing methane mitigation in ruminants through feed additive combinations: efficacy, interactions, and implementation challenges.Frontiers in microbiology · 2026Review
- Effects of 2-bromoethanesulfonate alone or in combination with calcium propionate or monensin on methane and gaseous hydrogen production during in vitro rumen fermentation.JDS communications · 2026Article
- A bromoform based Investigational Veterinary Product fed twice daily to lactating dairy cows had no adverse effects on eating, rumination, or locomotion behaviours.Veterinary and animal science · 2025Article
- Revisiting the direct and indirect impacts of enteric methane using a One Health perspective.Animal frontiers : the review magazine of animal agriculture · 2025Article
- Stacking Interventions Enhances Carbon Removals and Profitability of Livestock Production Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mitigating enteric methane emissions: An overview of methanogenesis, inhibitors and future prospects.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Differential effects of 3-nitrooxypropanol supplementation on milk fatty acid profiles in 3 different dairy breeds.JDS communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Ruminants, particularly dairy and beef cattle, contribute to climate change through mostly enteric methane emissions. Several mitigating options have been proposed, including the feed additive 3-nitrooxypropanol (3-NOP). The objectives of this study were to explain the variability in the mitigating effect of 3-NOP and to investigate the interaction between diet composition and 3-NOP dose, using meta-analytical approaches. Data from 13 articles (14 experiments) met the selection criteria for inclusion in the meta-analysis, and 48 treatment means were used for the analysis. Mean differences were calculated as 3-NOP treatment mean minus control treatment mean and then expressed as a percentage of the control mean. Three types of models were developed: (1) one including 3-NOP dose, overall mean, and individual covariate; (2) a combination of neutral detergent fiber (NDF), 3-NOP dose, and overall mean; and (3) one selected model from all combinations of up to 5 covariates, which were compared using a leave-one-out cross validation method. Models including only 3-NOP dose resulted in a significant reduction of 32.7%, 30.9%, and 32.6% for CH
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.