ArticleThe Journal of allergy and clinical immunology2023
Cold exposure impairs extracellular vesicle swarm-mediated nasal antiviral immunity.
Article in The Journal of allergy and clinical immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 74 citations in OpenAlex.
- Ambient temperature variability and newly diagnosed tuberculosis: Evidence from a time-stratified case-crossover study.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Diurnal temperature range and daily mean temperature in relation to multimorbidity among middle-aged or older Chinese adults: insights from the CHARLS.BMC public health · 2026Article
- Mitigating indoor risk of airborne infections using COJournal of environmental health science & engineering · 2026Article
- Rental housing may contribute to racial and ethnic disparities in upper respiratory infections.medRxiv : the preprint server for health sciences · 2026Article
- Dietary Saturated Fatty Acids as Evolutionarily Conserved Signals of Immune Activation.DNA and cell biology · 2026Review
- Interindividual variability in immune response to AAV ocular gene delivery across species impedes immunomonitoring.JCI insight · 2026Article
- Molecular pattern of acquiring upper respiratory infection.Frontiers in medicine · 2026Article
- Age-stratified respiratory viral detection patterns and exploratory environmental associations in a tertiary-care hospital testing cohort in Istanbul, Türkiye.Frontiers in microbiology · 2026Article
- Extracellular vesicles decoying across host immunity.Journal of leukocyte biology · 2025Review
- Crosstalk between airway epithelial cells and mast cells in airway inflammation.Respiratory research · 2025Review
- PMEnvironment & health (Washington, D.C.) · 2025Article
- Impact of airflow stimulation: mild cold airflow is more sensitive to influenza virus infection.Journal of thoracic disease · 2025Article
- Mathematical Modeling of Influenza Dynamics: Integrating Seasonality and Gradual Waning Immunity.Bulletin of mathematical biology · 2025Article
- Nocturnal respiratory support with nasal high flow in hypercapnic COPD: a randomised, crossover trial.ERJ open research · 2025Article
- Lipid metabolism, remodelling and intercellular transfer in the CNS.Nature reviews. Neuroscience · 2025Review
- Ear, nose and throat disorders and international travel.Tropical diseases, travel medicine and vaccines · 2025Review
- Low temperature increases adenovirus replication via intracellular alkalization.Frontiers in cellular and infection microbiology · 2025Article
- Improving influenza prediction in Quanzhou, China: an ARIMAX model integrated with meteorological drivers.Frontiers in public health · 2025Article
- Time series analysis of low-concentration air pollution and hospital respiratory disease outpatient visits.Frontiers in public health · 2025Article
- Inflammaging Markers in the Extremely Cold Climate: A Case Study of Yakutian Population.International journal of molecular sciences · 2024Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe human upper respiratory tract is the first site of contact for inhaled respiratory viruses and elaborates an array of innate immune responses. Seasonal variation in respiratory viral infections and the importance of ambient temperature in modulating immune responses to infections have been well recognized; however, the underlying biological mechanisms remain understudied.
objectiveWe investigated the role of nasal epithelium-derived extracellular vesicles (EVs) in innate Toll-like receptor 3 (TLR3)-dependent antiviral immunity.
methodsWe evaluated the secretion and composition of nasal epithelial EVs after TLR3 stimulation in human autologous cells and fresh human nasal mucosal surgical specimens. We also explored the antiviral activity and mechanisms of TLR3-stimulated EVs against respiratory viruses as well as the effect of cool ambient temperature on TLR3-dependent antiviral immunity.
resultsWe found that polyinosinic:polycytidylic acid, aka poly(I:C), exposure induced a swarm-like increase in the secretion of nasal epithelial EVs via the TLR3 signaling. EVs participated in TLR3-dependent antiviral immunity, protecting the host from viral infections through both EV-mediated functional delivery of miR-17 and direct virion neutralization after binding to virus ligands via surface receptors, including LDLR and ICAM-1. These potent antiviral immune defense functions mediated by TLR3-stimulated EVs were impaired by cold exposure via a decrease in total EV secretion as well as diminished microRNA packaging and antiviral binding affinity of individual EV.
conclusionTLR3-dependent nasal epithelial EVs exhibit multiple innate antiviral mechanisms to suppress respiratory viral infections. Furthermore, our study provides a direct quantitative mechanistic explanation for seasonal variation in upper respiratory tract infection prevalence.
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