Evidence map›Paper›PMID 36494045›Full record

ArticleContemporary clinical trials2023

Study protocol for a revised randomized trial: Remotely delivered Tai Chi and wellness for Gulf War illness.

Barbara L Niles, Stephanie Grossman, Maria McQuade, Daniel Grossman, Anica Pless Kaiser, Brian Muccio, Ben Warner, Chenchen Wang, DeAnna L Mori

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02661997 (Novel Interventions for Gulf War Veterans' Illnesses), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02661997 nacompletednot on this map

Novel Interventions for Gulf War Veterans' Illnesses

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2017 to 2025Enrolled114ConditionsGulf War Veteran's IllnessArmsTai Chi Intervention, Wellness Intervention
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Barbara L NilesNational Center for PTSD, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, United States of America. Electronic address: Barbara.Niles@va.gov.
Stephanie GrossmanNational Center for PTSD, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, United States of America.
Maria McQuadeNational Center for PTSD, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, United States of America.
Daniel GrossmanNational Center for PTSD, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, United States of America.
Anica Pless KaiserNational Center for PTSD, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, United States of America.
Brian MuccioBody Movement Solutions, 2700 N. Highway A1A, 2-101, Indialantic, FL 32903, United States of America.
Ben WarnerYang Martial Arts Association Boston, 756 South Street, Roslindale, MA, 02131, United States of America.
Chenchen WangCenter for Integrative Medicine, Division of Rheumatology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States of America.
DeAnna L MoriVA Boston Healthcare System and Boston University School of Medicine, Boston, MA, United States of America.
VA Boston Healthcare System · US3-Sigma Research (United States) · USInstitute of Contemporary Art · USTufts University · US

Funding

Tai Chi Mind-body Exercise for the Treatment of Post-traumatic Stress DisorderR01AT006367 · NCCIH · TUFTS MEDICAL CENTER · PI WANG, CHENCHEN · 2011 to 2014
$2.9M
Tai Chi for Knee OsteoarthritisR01AT005521 · NCCIH · TUFTS MEDICAL CENTER · PI WANG, CHENCHEN · 2010 to 2013
$2.4M
Mentoring and Research in Patient-Oriented Integrative MedicineK24AT007323 · NCCIH · TUFTS MEDICAL CENTER · PI WANG, CHENCHEN · 2014 to 2023
$1.8M
Novel Interventions for Gulf War Veterans' IllnessesI01CX001422 · VA · VA BOSTON HEALTH CARE SYSTEM · PI MORI, DEANNA L., NILES, BARBARA L. · 2016 to 2024
–
CSRD VA I01 CX001422NCCIH NIH HHS K24 AT007323NCCIH NIH HHS R01 AT005521NCCIH NIH HHS R01 AT006367
6 · The paper itself

Abstract

backgroundMany of the 700,000 American military personnel deployed to the Persian Gulf region in 1990 and 1991 have since reported health symptoms of unknown etiology. This cluster of symptoms has been labeled Gulf War Illness and include chronic musculoskeletal pain, fatigue, headaches, memory and attention difficulties, gastrointestinal complaints, skin abnormalities, breathing problems, and mood and sleep problems [1,2]. There have been few high-quality intervention trials and no strong evidence to support available treatments [3]. Tai Chi is an ancient Chinese martial art with benefits that include enhancing physical and mental health and improving quality of life for those with chronic conditions. PROPOSED

methodsIn this randomized controlled trial, GW Veterans are randomly assigned to either Tai Chi or a Wellness control condition, with both remotely delivered intervention groups meeting twice a week for 12 weeks. The primary aim is to examine if Tai Chi is associated with greater improvements in GWI symptoms in Veterans with GWI compared to a Wellness intervention. Participants will receive assessments at baseline, 12 weeks (post-intervention), and follow-up assessments 3- and 9-months post-intervention. The primary outcome measure is the Brief Pain Inventory that examines pain intensity and pain interference.

conclusionThis trial will produce valuable results that can have a meaningful impact on healthcare practices for GWI. If proven as a helpful treatment for individuals with GWI, it would support the implementation of remotely delivered Tai Chi classes that Veterans can access from their own homes.

Indexed as

Musculoskeletal PainPersian Gulf SyndromeTai JiVeteransHumansQuality of LifeRandomized Controlled Trials as TopicComplementaryGulf war illnessIntegrativeTai chiVeteranWellness

Identifiers

PMID36494045
PMCPMC9918688
OpenAlexW4310797322

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.