Evidence map›Paper›PMID 36493974›Full record

ArticleNeurobiology of disease2023

Long wavelength light reduces the negative consequences of dim light at night.

Huei-Bin Wang, David Zhou, Shu Hon Christopher Luk, Hye In Cha, Amanda Mac, Rim Chae, Anna Matynia, Ben Harrison, Sina Afshari, Gene D Block and 2 more

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Ocular manifestations in autism spectrum disorder.International journal of ophthalmology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Huei-Bin WangMolecular, Cellular, Integrative Physiology Graduate Program, David Geffen School of Medicine, University of California Los Angeles, USA; Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USA.
David ZhouDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USA.
Shu Hon Christopher LukDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USA.
Hye In ChaDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USA.
Amanda MacDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USA.
Rim ChaeDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USA.
Anna MatyniaLaboratory of Ocular Molecular and Cellular Biology and Genetics, Jules Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, USA.
Ben HarrisonKorrus Inc, Los Angeles, CA, USA.
Sina AfshariKorrus Inc, Los Angeles, CA, USA.
Gene D BlockDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USA.
Cristina A GhianiDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, USA; Intellectual and Developmental Disabilities Center, David Geffen School of Medicine, University of California Los Angeles, USA.
Christopher S ColwellDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USA; Intellectual and Developmental Disabilities Center, David Geffen School of Medicine, University of California Los Angeles, USA. Electronic address: ccolwell@mednet.ucla.edu.
Neurobehavioral Systems · USUniversity of California, Los Angeles · US

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani, SUMA JACOB · 2020 to 2026
$9.6M
17/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UCLAU01DA050987 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUSAN Y BOOKHEIMER, Mirella Dapretto · 2020 to 2026
$9.0M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
Time restricted feeding rescues circadian and motor dysfunction in a mouse model of Huntington's diseaseR21NS115041 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLWELL, CHRISTOPHER SCOTT, PAUL, KETEMA N · 2020 to 2021
$547k
NICHD NIH HHS P50 HD103557NICHD NIH HHS U54 HD087101NIDA NIH HHS U01 DA050987NINDS NIH HHS R21 NS115041
6 · The paper itself

Abstract

Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycles, and they may be particularly vulnerable to the impact of circadian disruptors. We have previously shown that a 2-weeks exposure to dim light at night (DLaN) disrupts diurnal rhythms, increases repetitive behaviors and reduces social interactions in contactin-associated protein-like 2 knock out (Cntnap2 KO) mice. The deleterious effects of DLaN may be mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin, which is maximally sensitive to blue light (480 nm). In this study, the usage of a light-emitting diode array enabled us to shift the spectral properties of the DLaN while keeping the intensity of the illumination at 10 lx. First, we confirmed that the short-wavelength enriched lighting produced strong acute suppression of locomotor activity (masking), robust light-induced phase shifts, and cFos expression in the suprachiasmatic nucleus in wild-type (WT) mice, while the long-wavelength enriched lighting evoked much weaker responses. Opn4

Indexed as

Circadian RhythmRetinal Ganglion CellsAnimalsLightMembrane ProteinsMiceNerve Tissue ProteinsSuprachiasmatic NucleusCNTNAP2 protein, mouseMembrane ProteinsNerve Tissue ProteinsAmygdalaAutism spectrum disordercFosCircadianCntnap2 knock outLight pollutionMelanopsinMice

Identifiers

PMID36493974
PMCPMC10594349
OpenAlexW4311769541

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.