ArticleFertility and sterility2023
Sperm human papillomavirus infection and risk of idiopathic recurrent pregnancy loss: insights from a multicenter case-control study.
Article in Fertility and sterility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Autoimmunity and Inflammaging in Male Infertility.Clinical reviews in allergy & immunology · 2026Review
- Expanding the case for gender-neutral human papillomavirus vaccination in South Africa: Emerging neonatal and ethical considerations.African journal of primary health care & family medicine · 2025Article
- HPV-51 or HPV-52 Infection Could Impair Sperm Quality in Infertile Patients: A Preliminary Study on Our Experience from North-Western Italy.Tropical medicine and infectious disease · 2025Article
- Ultrasensitive detection and quantification of bovine Deltapapillomavirus in the semen of healthy horses.Scientific reports · 2025Article
- Papillomavirus infection and male infertility: A systematic review and meta-analysis.Health science reports · 2024Review
- Molecular study of the presence and transcriptional activity of HPV in semen.Journal of endocrinological investigation · 2024Article
- HPV-related diseases in male patients: an underestimated conundrum.Journal of endocrinological investigation · 2024Review
- Impact of high-risk and low-risk human papillomavirus infections on the male genital tract: effects on semen inflammation and sperm quality.Frontiers in cellular and infection microbiology · 2024Article
- Molecular detection of transcriptionally active ovine papillomaviruses in commercial equine semen.Frontiers in veterinary science · 2024Article
- Lipids, lipid-modified drug target genes, and the risk of male infertility: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Immune Regulation of Seminal Plasma on the Endometrial Microenvironment: Physiological and Pathological Conditions.International journal of molecular sciences · 2023Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test the hypothesis claiming an association between human papilloma virus (HPV) sperm infection and idiopathic recurrent pregnancy loss (RPL).
designMulticenter retrospective case-control study.
settingThree university hospitals. PATIENT(S): Cases included men belonging to couples affected by first trimester idiopathic RPL. Controls included men belonging to couples with proven fertility and no history of pregnancy loss; RPL was defined as the previous loss of 2 or more pregnancies. Couples were defined as "fertile" if they achieved a full-term pregnancy within the year before enrollment in the study. All participants conceived without assistance. MAIN OUTCOME MEASURE(S): The association between HPV DNA sperm infection, as identified using polymerase chain reaction, and RPL.
resultsThe HPV DNA sperm infection was detected in 23 of 117 cases (20%; 95% confidence interval [CI]: 13%, 28%) and in 3 of 84 controls (4%; 95% CI; 1%, 10%) (P<.001). A comparison across baseline characteristics and multiple regression analysis did not identify any potentially confounding factors. Multivariate regression models showed a significant association between HPV DNA sperm infection and RPL (adjusted odds ratio, 7.44; 95% CI: 2.08, 26.58; P=.002 [Model 1]; adjusted odds ratio, 8.96; 95% CI: 2.41, 33.44; P=.001 [Model 2]).
conclusionsThe prevalence of HPV sperm infection was significantly higher in couples affected by RPL than in their fertile counterparts. Notably, the semen sample was infected by HPV in approximately 1 out of 5 patients.
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