ArticleCell2022
Domestic dog lineages reveal genetic drivers of behavioral diversification.
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Dog Breeds for the Future: Theoretical Assessment of Strategies for Enhancing the Behavioural Reliability of Existing Dog Breeds, or Developing New Ideal Urban Companion Dogs.Animals : an open access journal from MDPI · 2026Review
- Gut microbiome alterations in canine idiopathic epilepsy: a pairwise case-control study.Animal microbiome · 2026Article
- Participation in Breed-Specific Cynological Activities Is Associated with Behavioral Variation in Terrier-Type Dogs: A C-BARQ Study.Animals : an open access journal from MDPI · 2026Article
- An interpretable machine learning framework for dog breed inference and ancestry decomposition.bioRxiv : the preprint server for biology · 2026Article
- Gut Microbiome Alterations in Canine Idiopathic Epilepsy: A Pairwise Case-Control Study.bioRxiv : the preprint server for biology · 2026Article
- Genomic insights into six dog breeds owned in India: a ddRAD sequencing approach.BMC genomics · 2026Article
- Phenome-wide study connects behavioral genetics of odor detection dogs with temperament traits.Scientific reports · 2026Article
- Showing Behaviour in One Hundred and One Dogs: Gazing, Breed and Cephalic Index.Animals : an open access journal from MDPI · 2026Article
- Professional perspectives on recurrent characteristics of dogs with separation-related problems: a qualitative study in three nordic countries.Scientific reports · 2026Article
- Changes in cognitive performance following repeated exposure to a hand-touch learning task across breed clades of domestic dogs (Canis familiaris).Animal cognition · 2026Article
- Behavioural susceptibility to environmental influences in obesity- evidence from a companion animal model.BMC veterinary research · 2026Article
- Attention and improvement: social learning reveals two behavioural dimensions behind dog-human interactions.Evolutionary human sciences · 2026Article
- Spatial Problem-Solving in Working Dogs: The Combined Effect of Body-Size Awareness, Social Learning and Functional Breed Selection.Animals : an open access journal from MDPI · 2025Article
- The behavioral profile of a detection dog is tuned for the dog's role and their environment.Scientific reports · 2025Article
- Article
- Genetic testing predicts appearance but not behavior in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A 120-y time series of genomes reveals the consequences of closed breeding in German Shepherd Dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Whole-Genome Data to Investigate Recent and Historical Dog Introgression Patterns in Italian Wolves.Ecology and evolution · 2025Article
- Determinants of de novo mutations in extended pedigrees of 43 dog breeds.Genome biology · 2025Article
Corrections and comments
- Commented on by
Authors and funding
3 authors.
Funding
Abstract
Selective breeding of domestic dogs has generated diverse breeds often optimized for performing specialized tasks. Despite the heritability of breed-typical behavioral traits, identification of causal loci has proven challenging due to the complexity of canine population structure. We overcome longstanding difficulties in identifying genetic drivers of canine behavior by developing a framework for understanding relationships between breeds and the behaviors that define them, utilizing genetic data for over 4,000 domestic, semi-feral, and wild canids and behavioral survey data for over 46,000 dogs. We identify ten major canine genetic lineages and their behavioral correlates and show that breed diversification is predominantly driven by non-coding regulatory variation. We determine that lineage-associated genes converge in neurodevelopmental co-expression networks, identifying a sheepdog-associated enrichment for interrelated axon guidance functions. This work presents a scaffold for canine diversification that positions the domestic dog as an unparalleled system for revealing the genetic origins of behavioral diversity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.