Evidence map›Paper›PMID 36493386›Full record

Trial reportCannabis and cannabinoid research2024

Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study.

Lucy A Chester, Amir Englund, Edward Chesney, Dominic Oliver, Jack Wilson, Simina Sovi, Alex M Dickens, Matej Oresic, Tuomas Linderman, John Hodsoll and 5 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cannabis and cannabinoid research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Circulating endocannabinoids in children and adolescents: associations with anxiety and the impact of selective serotonin reuptake inhibitors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
  3. Trial
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Interactions between cannabis use and chronic pain on sleep architecture: Findings from in-home EEG recordings.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Lucy A ChesterDepartment of Psychosis Studies and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.ORCID 0000-0002-7813-0281
Amir EnglundNational Addiction Centre (NAC), Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Edward ChesneyDepartment of Psychosis Studies and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Dominic OliverDepartment of Psychosis Studies and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Jack WilsonThe Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, New South Wales, Australia.
Simina SoviDepartment of Psychosis Studies and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Alex M DickensTurku Bioscience Center, University of Turku and Åbo Akademi University, Turku, Finland.
Matej OresicTurku Bioscience Center, University of Turku and Åbo Akademi University, Turku, Finland.
Tuomas LindermanTurku Bioscience Center, University of Turku and Åbo Akademi University, Turku, Finland.
John HodsollDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Amedeo MinichinoDepartment of Psychosis Studies and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
John StrangNational Addiction Centre (NAC), Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Robin M MurrayDepartment of Psychosis Studies and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Tom P FreemanDepartment of Psychology, University of Bath, Bath, United Kingdom.
Philip McGuireDepartment of Psychosis Studies and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
King's College London · GBÅbo Akademi University · FIUniversity of Bath · GBUNSW Sydney · AU

Funding

Medical Research Council
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Arachidonic AcidsCannabidiolCannabisHallucinogensPolyunsaturated AlkamidesCannabinoid Receptor AgonistsCross-Over StudiesDouble-Blind MethodDronabinolEndocannabinoidsHumansReceptors, CannabinoidanandamideArachidonic AcidsCannabidiolCannabinoid Receptor AgonistsDronabinolEndocannabinoidsHallucinogensPolyunsaturated AlkamidesReceptors, Cannabinoid2-arachidonoylglycerolanandamidecannabisCBDendocannabinoidsTHC

Identifiers

PMID36493386
PMCPMC10874814
OpenAlexW4311020847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.