ArticleScience advances2022
PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Whole genome copy number variation analysis to detect genomic regions for resistance to Haemonchus contortus in Sheep.BMC genomics · 2026Article
- Oncogenic PIK3CA mutations shape an immunoregulatory microenvironment in mosaic overgrowth disorders.PNAS nexus · 2026Article
- Conventional and alternative approaches for targeting PIK3CA and PTEN alterations in head and neck, breast, and other cancers.Advances in biological regulation · 2026Review
- Effects of alpelisib treatment on murineAdipocyte · 2025Article
- Abdominal Lipedema: Clinical Diagnosis and Management Through a Proposed Diagnostic Algorithm.Aesthetic plastic surgery · 2025Article
- H3K18 lactylation-hexokinase 2 positive feedback loop promotes osteogenesis of ASPCs in facial infiltrating lipomatosis.Stem cell research & therapy · 2025Article
- First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum.European journal of human genetics : EJHG · 2025Article
- Article
- Activating PIK3CA mutations in adipose-derived stem cells drive mutant-like phenotypes of wild-type cells in macrodactyly.Cell death & disease · 2025Article
- Quantification of Lateralized Overgrowth and Genotype-Driven Tissue Composition.Clinical genetics · 2025Article
- Ablation of PI3Kγ in neurons protects mice from diet-induced obesity MASLD and insulin resistance.iScience · 2025Article
- Pharmacologic management of HR+/HER2- mBC: a clinically oriented review.Frontiers in oncology · 2025Review
- Paediatric strategy forum for medicinal product development of PI3-K, mTOR, AKT and GSK3β inhibitors in children and adolescents with cancer.European journal of cancer (Oxford, England : 1990) · 2024Review
- Targeted therapy for capillary-venous malformations.Signal transduction and targeted therapy · 2024Article
- PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis.The Journal of clinical investigation · 2024Article
- A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism.Nature metabolism · 2024Article
- A Novel Eight-Gene Signature for Lipid Metabolism Predicts the Progression of Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition.The Journal of experimental medicine · 2023Article
- Review
- Heterogeneity and potential therapeutic insights for triple-negative breast cancer based on metabolic-associated molecular subtypes and genomic mutations.Frontiers in pharmacology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 4 institutions in 1 country.
Sophia LadraaUniversité Paris Cité, Paris, France.ORCID 0000-0002-6229-3043
Lola ZerbibUniversité Paris Cité, Paris, France.
Charles BayardUniversité Paris Cité, Paris, France.
Antoine FraissenonINSERM U1151, Institut Necker-Enfants Malades, Paris, France.ORCID 0000-0003-4414-1246
Quitterie VenotUniversité Paris Cité, Paris, France.
Gabriel MorinUniversité Paris Cité, Paris, France.ORCID 0000-0002-8423-6701
Alexandre P GarneauUniversité Paris Cité, Paris, France.ORCID 0000-0003-1450-0949
Pierre IsnardUniversité Paris Cité, Paris, France.
Célia ChapelleUniversité Paris Cité, Paris, France.
Clément HoguinINSERM U1151, Institut Necker-Enfants Malades, Paris, France.
Sylvie FraitagService d'Anatomie pathologique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
Jean-Paul DuongUniversité Paris Cité, Paris, France.ORCID 0000-0002-3051-2141
Laurent GuibaudINSERM U1151, Institut Necker-Enfants Malades, Paris, France.
Alix BesançonUniversité Paris Cité, Paris, France.
Sophie KaltenbachUniversité Paris Cité, Paris, France.
Patrick VillareseLaboratoire d'Oncohématologie, Hôpital Necker-Enfants Malades, AP-HP, Paris, France.ORCID 0000-0003-1625-3785
Vahid AsnafiUniversité Paris Cité, Paris, France.
Christine BroissandPharmacie, Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
Nicolas GoudinNecker Bio-Image Analysis, INSERM US24/CNRS UMS 3633, Paris, France.ORCID 0000-0002-3967-4016
Michael DussiotUniversité Paris Cité, Paris, France.
Ivan NemazanyyPlatform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS 3633, Paris, France.ORCID 0000-0001-8080-839X
Thomas VielPlateforme Imageries du Vivant, Université de Paris, PARCC, INSERM, Paris, France.ORCID 0000-0002-0756-9166
Gwennhael AutretPlateforme Imageries du Vivant, Université de Paris, PARCC, INSERM, Paris, France.ORCID 0000-0001-7335-350X
Céline Cruciani-GuglielmacciUniversité Paris Cité, Paris, France.ORCID 0000-0002-2562-5360
Jessica DenomUniversité Paris Cité, Paris, France.ORCID 0000-0002-8507-058X
Julie BruneauUniversité Paris Cité, Paris, France.
Bertrand TavitianUniversité Paris Cité, Paris, France.ORCID 0000-0002-5349-8194
Christophe LegendreUniversité Paris Cité, Paris, France.
Julien DairouUniversité Paris Cité, Paris, France.
Jean-Marc LacorteLaboratoire de Biochimie Endocrinienne et Oncologique, Hôpital La Pitié Salpêtrière, AP-HP, Paris, France.ORCID 0000-0002-3454-0406
Pacifique LevyLaboratoire de Biochimie Endocrinienne et Oncologique, Hôpital La Pitié Salpêtrière, AP-HP, Paris, France.
Mario PendeUniversité Paris Cité, Paris, France.
Michel PolakUniversité Paris Cité, Paris, France.
Guillaume CanaudUniversité Paris Cité, Paris, France.ORCID 0000-0001-8146-7996
Inserm · FRHôpital Necker-Enfants Malades · FRCentre National de la Recherche Scientifique · FRSorbonne Université · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Adipose TissueClass I Phosphatidylinositol 3-KinasesGain of Function MutationAnimalsMiceMutationPhenotypeClass I Phosphatidylinositol 3-KinasesPik3ca protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.