Evidence map›Paper›PMID 36484948›Full record

ArticleOphthalmology and therapy2023

Serial Sessions of a Novel Low-Level Light Therapy Device for Home Treatment of Dry Eye Disease.

Giuseppe Giannaccare, Sabrina Vaccaro, Marco Pellegrini, Massimiliano Borselli, Giovanna Carnovale Scalzo, Andrea Taloni, Rocco Pietropaolo, Ali Saeed Odadi, Adriano Carnevali

Open access · goldAbstract read
In one paragraph

Article in Ophthalmology and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Giuseppe GiannaccareDepartment of Ophthalmology, University Magna Græcia of Catanzaro, Viale Europa, 88100, Germaneto, Catanzaro, Italy. giuseppe.giannaccare@unicz.it.ORCID http://orcid.org/0000-0003-2617-0289
Sabrina VaccaroDepartment of Ophthalmology, University Magna Græcia of Catanzaro, Viale Europa, 88100, Germaneto, Catanzaro, Italy.
Marco PellegriniDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Massimiliano BorselliDepartment of Ophthalmology, University Magna Græcia of Catanzaro, Viale Europa, 88100, Germaneto, Catanzaro, Italy.
Giovanna Carnovale ScalzoDepartment of Ophthalmology, University Magna Græcia of Catanzaro, Viale Europa, 88100, Germaneto, Catanzaro, Italy.
Andrea TaloniDepartment of Ophthalmology, University Magna Græcia of Catanzaro, Viale Europa, 88100, Germaneto, Catanzaro, Italy.
Rocco PietropaoloDepartment of Ophthalmology, University Magna Græcia of Catanzaro, Viale Europa, 88100, Germaneto, Catanzaro, Italy.
Ali Saeed OdadiOdadi Eye Cosmetic Center and Dry Eye, Abha, Saudi Arabia.
Adriano CarnevaliDepartment of Ophthalmology, University Magna Græcia of Catanzaro, Viale Europa, 88100, Germaneto, Catanzaro, Italy.
Magna Graecia University · ITUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to evaluate the changes that a recently developed at-home device using low-level light therapy (LLLT) produced in signs and symptoms of patients with dry eye disease (DED) owing to meibomian gland dysfunction (MGD).

methodsIn this prospective study, patients with DED owing to MGD not successfully responding to first-line therapy (tear substitutes and eye lid hygiene) were treated with four serial sessions (every other day) of mask based on LLLT technology and dedicated for home use (my-mask

resultsOverall, 17 patients (3 male, 14 female; mean age 61.47 ± 11.93 years) were enrolled and all of them regularly completed the entire cycle of four sessions without reporting any adverse event. The mean values of NIKBUT first and NIKBUT average increased significantly after treatment (from 5.29 ± 2.60 at T0 to 9.04 ± 3.49 s at T1 [P = 0.001] and from 9.40 ± 3.81 to 11.28 ± 2.81 s [P = 0.017]); in parallel, the mean value of TMH increased significantly from 0.27 ± 0.06 to 0.32 ± 0.09 mm (P = 0.029). Conversely, there were not statistically significant differences for MGL (P = 0.346). In addition, the mean value of OSDI score decreased after treatment (from 32.00 ± 7.96 at T0 to 20.71 ± 8.03 at T1; P < 0.001).

conclusionsOne week of serial sessions of a newly developed LLLT device for home use significantly improved tear film production and stability along with ocular discomfort symptoms in patients with DED owing to MGD. These findings open up a new scenario for patients with MGD who can enjoy the unique benefits of LLLT at home.

Indexed as

Dry eyeHome maskLLLTLow-level light therapyMeibomian gland dysfunction

Identifiers

PMID36484948
PMCPMC9834479
OpenAlexW4310946330

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.