ArticleAnnals of surgical oncology2023
Does Using Indocyanine Green Fluorescence Imaging for Tumors Help in Determining the Safe Surgical Margin in Real-Time Navigation of Laparoscopic Hepatectomy? A Retrospective Study.
Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06219096 (Application of Indocyanine Green), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Application of Indocyanine Green(ICG)@Human Serum Albumin(HSA) Complexes in Fluorescence Image-Guided Laparoscopic Anatomical Liver Resection: A Prospective, Double-Blinded, Randomized Controlled Trial
Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Progress in the Design and Clinical Application of Probes for Fluorescence-Guided Laparoscopic Surgery.Chemical & biomedical imaging · 2026Review
- Optimizing indocyanine green positive staining with total liver volume-normalized dosing in robotic hepatectomy: an image-based analysis.Journal of robotic surgery · 2025Observational
- Laparoscopic hepatectomy and near-infrared fluorescence based on the concept of "biliary territory" in the treatment of hepatolithiasis: a propensity score-matched study with videos.Hepatobiliary surgery and nutrition · 2025Article
- Review
- Role of indocyanine green fluorescence imaging in margin assessment and recurrence-free survival in laparoscopic parenchyma-sparing hepatectomy for neuroendocrine tumor liver metastases.Surgical endoscopy · 2025Article
- Perioperative and recurrence-free survival outcomes after laparoscopic hepatectomy for colorectal cancer liver metastases using indocyanine green fluorescence imaging: an inverse probability treatment weighted analysis.Surgical endoscopy · 2025Article
- Case Report: Selective hepatic resection guided by indocyanine green short-wave infrared fluorescence imaging in a dog with multifocal liver lesions.Frontiers in veterinary science · 2025Article
- The Effect of Hepatic Surgical Margins of Colorectal Liver Metastases on Prognosis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Cutting-edge insights: near-infrared imaging for surgical margin assessment in head and neck tumor resection: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2024Article
- Review
- Pay attention to the application of indocyanine green fluorescence imaging technology in laparoscopic liver cancer resection.World journal of clinical cases · 2024Article
- Article
- Indocyanine green fluorescence in gastrointestinal surgery: Appraisal of current evidence.World journal of gastrointestinal surgery · 2023Review
- Application of a Self-developed, Low-budget Indocyanine Green Camera in Surgical Imaging - a Single Institution's Experiences.Journal of fluorescence · 2023Article
- Minimally invasive surgery for hepatocellular carcinoma.Journal of the Chinese Medical Association : JCMA · 2023Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThis study aims to investigate whether indocyanine green (ICG) tumor imaging helps determine the safe surgical margin in laparoscopic hepatectomy. PATIENTS AND
methodsEighty-six patients with hepatic malignancies [including hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM)] were included in this study. ICG-R15 testing was performed 5-7 days before surgery. Fluorescence staining of the tumor was detected by a fluorescent laparoscope, and the width of fluorescence band surrounding tumor was measured by an electronic vernier caliper.
resultsThe positive rate of hepatic malignant lesions successfully stained by ICG fluorescence was 96.0% (95/99). HCC with better differentiation demonstrated non-rim fluorescence patterns, while cases with poor differentiation demonstrated rim patterns. CRLM uniformly demonstrated rim pattern. The width of fluorescence surrounding tumors was 0 in HCC with non-rim patterns. The minimum width of fluorescence surrounding tumors in poor differentiated HCC and CRLM were 2.4 ± 1.9 mm and 2.8 ± 2.5 mm, respectively, with no significant difference (P > 0.05). ICG fluorescence imaging revealed eight small lesions, which were not detected preoperatively in seven patients, of which five lesions were confirmed as malignancies by pathology.
conclusionsResection along the ICG fluorescence edge can supply a safe surgical margin only for CRLM, but not for HCC. Otherwise, ICG fluorescence tumor imaging can preliminarily determine the pathological type of hepatic malignancies and histological differentiation of HCC and help detect small lesions that cannot be detected preoperatively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.