Evidence map›Paper›PMID 36484893›Full record

ArticleBehavior genetics2023

Associations Between Attention Deficit Hyperactivity Disorder Symptom Dimensions and Disordered Eating Symptoms in Adolescence: A Population-Based Twin Study.

Zeynep Yilmaz, Mary J Quattlebaum, Pratiksha S Pawar, Laura M Thornton, Cynthia M Bulik, Kristin N Javaras, Shuyang Yao, Paul Lichtenstein, Henrik Larsson, Jessica H Baker

Open access · goldAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavior genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Zeynep YilmazNational Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark.
Mary J QuattlebaumDepartment of Psychology, University of South Carolina, Columbia, SC, USA.
Pratiksha S PawarDr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
Laura M ThorntonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kristin N JavarasDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Shuyang YaoDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Henrik LarssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jessica H BakerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Jhbaker@med.unc.edu.
Karolinska Institutet · SEUniversity of North Carolina at Chapel Hill · USDr. D.Y. Patil Vidyapeeth, Pune · INMcLean Hospital · USUniversity of South Carolina · US

Funding

Eating Disorders Genetics Initiative (EDGI)R01MH120170 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2019 to 2023
$7.2M
Biomedical-Behavioral Interface: Prevention and Developmental Sciences TrainingT32GM081740 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PRINZ, RONALD J · 2008 to 2022
$4.5M
Postdoctoral Research Training in Eating DisordersT32MH076694 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2007 to 2016
$1.8M
Understanding the Effects of Acute Stressors and Negative Emotion on Eating Behavior in Binge-Eating Disorder: The Role of Stressor-Induced Changes in Reward and Cognitive ControlK23DK120517 · NIDDK · MCLEAN HOSPITAL · PI JAVARAS, KRISTIN N. · 2018 to 2022
$1.2M
BIOMARKERS OF WEIGHT CHANGE IN ANOREXIA NERVOSAK01MH106675 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAKER, JESSICA H · 2016 to 2019
$651k
Shared Genetic and Environmental Risk Factors for Anorexia Nervosa and Obsessive-Compulsive Disorder in DenmarkK01MH109782 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YILMAZ, ZEYNEP · 2016 to 2019
$620k
NIDDK NIH HHS K23 DK120517NIGMS NIH HHS T32 GM081740NIMH NIH HHS K01 MH106675NIMH NIH HHS K01 MH109782NIMH NIH HHS R01 MH120170NIMH NIH HHS T32 MH076694
6 · The paper itself

Abstract

Although bivariate associations between attention-deficit/hyperactivity disorder (ADHD) and eating disorders in adolescent girls and boys have been previously identified, the mechanistic link underlying the symptom-level associations remains unclear. We evaluated shared genetic and environmental influences on ADHD symptoms and disordered eating in 819 female and 756 male twins from the Swedish TCHAD cohort using bivariate models. Common additive genetic and unique environmental effects accounted for majority of ADHD and disordered eating associations in a differential manner. For girls, the strongest genetic correlation was observed for cognitive/inattention problems-bulimia (0.54), with genetic factors accounting for 67% of the phenotypic correlation. For boys, the strongest genetic correlations were observed for conduct problems-bulimia and hyperactivity-bulimia (~ 0.54), accounting for 83% and 95% of the phenotypic correlation, respectively. As per our findings, the risk of comorbidity and shared genetics highlights the need for preventative measures and specialized treatment for ADHD and disordered eating in both sexes.

Indexed as

Attention Deficit Disorder with HyperactivityBulimiaFeeding and Eating DisordersAdolescentComorbidityFemaleHumansMaleTwinsAttention-deficit/hyperactivity disorderDisordered eatingGeneticsPopulation cohortSex differencesSymptom-level associationsTwin study

Identifiers

PMID36484893
PMCPMC10167484
OpenAlexW4310943052

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.