Evidence map›Paper›PMID 36484845›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2023

Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients.

Xinyu Fang, Zenan Wu, Lu Wen, Yaoyao Zhang, Dandan Wang, Lingfang Yu, Yewei Wang, Yan Chen, Lei Chen, Hongyang Liu and 3 more

Abstract read
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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Xinyu Fang *Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Zenan Wu *Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Lu Wen *Department of Psychiatry, The Second People's Hospital of Jiangning District, Nanjing, People's Republic of China.
Yaoyao ZhangThe Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Dandan WangSchizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Lingfang YuSchizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Yewei WangSchizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Yan ChenSchizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Lei ChenDepartment of Psychiatry, School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Hongyang LiuThe Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Wei TangThe Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Xiangrong ZhangDepartment of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, People's Republic of China. drxrz@hotmail.com.
Chen ZhangSchizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. zhangchen645@gmail.com.
Shanghai Mental Health Center · CNJinzhou Kangning Hospital · CNNanjing Brain Hospital · CNShanghai Jiao Tong University · CNWenzhou Medical University · CNNanjing Jiangning Hospital · CN

Funding

the Key Project supproted by Medical Science and Technology Development Foundation, Nanjing Department of Health YKK20090the National Key Research and Development Program of China 2016YFC1307002the National Key Research and Development Program of China 2018YFC1314300the National Key Research and Development Program of China 2018YFC1314302the National Natural Science Foundation of China 81471358the National Natural Science Foundation of China 81571314the National Natural Science Foundation of China 81771450the National Natural Science Foundation of China 81971255the Science and Technology Development Program of Nanjing Medical University NMUB2019107
6 · The paper itself

Abstract

Rumination and childhood trauma are related to depressive symptoms in clinical and non-clinical individuals. This is the first study aimed to test the mediating effect of rumination on the relationship between childhood trauma and depressive symptoms in schizophrenia patients. A total of 313 schizophrenia patients were recruited in the present study. The 17-item Hamilton Depression Rating Scale (HAMD-17) was adopted to evaluate depressive symptoms, the short-form Childhood Trauma Questionnaire (CTQ-SF) and the 10-item Ruminative response scale (RRS-10) were utilized to assess the childhood trauma and rumination in patients, respectively. Our results showed that 168 schizophrenia patients (53.67%) had comorbid depressive symptoms. These patients with depressive symptoms had higher levels of childhood trauma [both CTQ-SF total scores and emotional abuse (EA), emotional neglect (EN), physical neglect (PN) subscale scores] and rumination (both RRS-10 total scores and brooding, reflection subscale scores) compared to patients without depressive symptoms. The stepwise logistic regression analysis identified that EN (OR 1.196, P = 0.003), PN (OR 1.1294, P < 0.001), brooding (OR 1.291, P < 0.001) and reflection (OR 1.481, P < 0.001) could independently predict the depressive symptoms in schizophrenia patients. Moreover, RRS-10 and its subscale scores could mediate the relationship between depressive symptoms and childhood trauma, especially EA, EN and PN in schizophrenia. Our preliminary findings suggest that the rigorous assessment and psychosocial interventions of rumination are important to alleviate the influence of childhood trauma on depressive symptoms in schizophrenia patients.

Indexed as

Adverse Childhood ExperiencesChild AbuseSchizophreniaChildDepressionHumansSurveys and QuestionnairesChildhood traumaDepressive symptomsRuminationSchizophrenia

Identifiers

PMID36484845
OpenAlexW4310941470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.