Evidence map›Paper›PMID 36484824›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2023

Insights into the role of the cobalt(III)-thiosemicarbazone complex as a potential inhibitor of the Chikungunya virus nsP4.

Daniel Oliveira Silva Martins, Rafael Aparecido Carvalho Souza, Marjorie Caroline Liberato Cavalcanti Freire, Nathalya Cristina de Moraes Roso Mesquita, Igor Andrade Santos, Débora Moraes de Oliveira, Nilson Nicolau Junior, Raphael Enoque Ferraz de Paiva, Mark Harris, Carolina Gonçalves Oliveira and 2 more

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In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Cobalt complexes in biology and medicine: enzymatic functions, pharmacological applications, and health challenges.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Daniel Oliveira Silva MartinsInstitute of Biomedical Sciences, Federal University of Uberlândia, Avenida Amazonas, 4C- Room 216, Umuarama, Uberlândia, MG, 38405-302, Brazil.
Rafael Aparecido Carvalho SouzaBioinorganic Chemistry Group, Institute of Chemistry, Federal University of Uberlândia, Uberlândia, MG, 38408-100, Brazil.
Marjorie Caroline Liberato Cavalcanti FreirePhysics Institute of São Carlos, University of São Paulo, São Carlos, SP, Brazil.
Nathalya Cristina de Moraes Roso MesquitaPhysics Institute of São Carlos, University of São Paulo, São Carlos, SP, Brazil.
Igor Andrade SantosInstitute of Biomedical Sciences, Federal University of Uberlândia, Avenida Amazonas, 4C- Room 216, Umuarama, Uberlândia, MG, 38405-302, Brazil.
Débora Moraes de OliveiraInstitute of Biomedical Sciences, Federal University of Uberlândia, Avenida Amazonas, 4C- Room 216, Umuarama, Uberlândia, MG, 38405-302, Brazil.
Nilson Nicolau JuniorMolecular Modeling Laboratory, Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Brazil.
Raphael Enoque Ferraz de PaivaDepartment of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.
Mark HarrisFaculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
Carolina Gonçalves OliveiraBioinorganic Chemistry Group, Institute of Chemistry, Federal University of Uberlândia, Uberlândia, MG, 38408-100, Brazil. carolina@ufu.br.
Glaucius OlivaPhysics Institute of São Carlos, University of São Paulo, São Carlos, SP, Brazil.
Ana Carolina Gomes JardimInstitute of Biomedical Sciences, Federal University of Uberlândia, Avenida Amazonas, 4C- Room 216, Umuarama, Uberlândia, MG, 38405-302, Brazil. jardim@ufu.br.
Universidade Federal de Uberlândia · BRUniversidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BRInstitute of Structural and Molecular Biology · GB

Funding

Wellcome TrustWellcome Trust 096670
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) is the causative agent of chikungunya fever, a disease that can result in disability. Until now, there is no antiviral treatment against CHIKV, demonstrating that there is a need for development of new drugs. Studies have shown that thiosemicarbazones and their metal complexes possess biological activities, and their synthesis is simple, clean, versatile, and results in high yields. Here, we evaluated the mechanism of action (MOA) of a cobalt(III) thiosemicarbazone complex named [Co

Indexed as

Chikungunya FeverChikungunya virusAntiviral AgentsCobaltHumansMolecular Docking SimulationViral Nonstructural ProteinsAntiviral AgentsCobaltViral Nonstructural ProteinsADME-ToxAntiviral activityChikungunya virusMechanism of actionMetal ionMolecular docking

Identifiers

PMID36484824
PMCPMC9735056
OpenAlexW4311282969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.