ReviewEuropean journal of nutrition2023
Inflammatory crosstalk between saturated fatty acids and gut microbiota-white adipose tissue axis.
Review in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- Microencapsulated OPO Enhances Intestinal SCFA Production by Optimizing Lipid Digestion and Regulating Bile Acid Metabolism in Mice.Foods (Basel, Switzerland) · 2026Article
- Mechanisms, Modulation, and Mitigation: Dietary-Gut Microbiome Strategies Against Antibiotic Resistance.Probiotics and antimicrobial proteins · 2026Review
- Gut microbiota and spleen-strengthening and dampness-dispelling therapies in obesity and related metabolic disorders: key mechanisms and therapeutic potential.Frontiers in pharmacology · 2026Review
- Cashew Nut Oil Improves Lipid Metabolism and Fat Liver Deposition in High-Fat Diet-Fed C57BL/6J Mice.Lipids · 2026Article
- Guidelines for diet-induced models of cardiometabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2025Review
- Dietary index for gut microbiota, metabolic syndrome, and long-term mortality: National Health and Nutrition Examination Survey, 2007-2018.Diabetology & metabolic syndrome · 2025Article
- Impact of the Dietary Fat Concentration and Source on the Fecal Microbiota of Healthy Adult Cats.Metabolites · 2025Article
- Article
- Time-restricted feeding alleviates arthritis symptoms augmented by high-fat diet.Frontiers in immunology · 2025Article
- Association between dietary inflammatory index and all-cause mortality risk in adults with coronary heart disease in the United States.Scientific reports · 2024Article
- Capsaicin Reduces Obesity by Reducing Chronic Low-Grade Inflammation.International journal of molecular sciences · 2024Article
- Soybean oil-based HFD induces gut dysbiosis that leads to steatosis, hepatic inflammation and insulin resistance in mice.Frontiers in microbiology · 2024Article
- Gut microbiota metabolites, redox status, and the related regulatory effects of probiotics.Heliyon · 2023Review
- Interactions between polyphenols fromCurrent research in food science · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purposeHigh-fat diets have different metabolic responses via gut dysbiosis. In this review, we discuss the complex interaction between the intake of long- and medium-chain saturated fatty acids (SFAs), gut microbiota, and white adipose tissue (WAT) dysfunction, particularly focusing on the type of fat.
resultsThe evidence for the impact of dietary SFAs on the gut microbiota-WAT axis has been mostly derived from in vitro and animal models, but there is now also evidence emerging from human studies. Most current reports show that, in response to high long- and medium-chain SFA diets, WAT functions are altered and can be modulated from microbial metabolites in several manners; and it appears to be also modified under conditions of obesity. SFAs overconsumption can reduce bacterial content and disrupt the gut environment. Both long- and medium-chain SFAs may contribute to proinflammatory cytokines release and TLR4 cascade signaling, either by regulation of endotoxemia markers or myristoylated protein. Palmitic and stearic acids have pathological effects on the intestinal epithelium, microbes, and inflammatory and lipogenic WAT profiles. While myristic and lauric acids display somewhat controversial outcomes, from probiotic effects and contribution to weight loss to cardiometabolic alterations from WAT inflammation.
conclusionIdentifying an interference of distinct types of SFA in the binomial gut microbiota-WAT may elucidate essential mechanisms of metabolic endotoxemia, which may be the key to triggering obesity, innovating the therapeutic tools for this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.