Evidence map›Paper›PMID 36484407›Full record

ArticleOncology reports2023

Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma.

Cheng Shen, Zhan Chen, Yong Zhang, Wei Xu, Rui Peng, Jie Jiang, Wenjing Zuo, Yihui Fan, Bing Zheng

Open access · hybridAbstract read
In one paragraph

Article in Oncology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Cheng ShenDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
Zhan ChenDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
Yong ZhangDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
Wei XuDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
Rui PengDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
Jie JiangDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
Wenjing ZuoDepartment of Orthopedics, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
Yihui FanDepartment of Pathogenic Biology, School of Medicine, Nantong University, Nantong, Jiangsu 226001, P.R. China.
Bing ZhengDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
Affiliated Hospital of Nantong University · CNNantong University · CNSecond Affiliated Hospital of Nantong University

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal cell carcinoma (RCC) remains one of the most lethal urinary tumors in East Asia despite great advancements in treatment strategies in recent years. Ribosomal protein S20 (RPS20) is considered a new oncogene; however, little information is available on its expression, regulation and biological function in patients with RCC. In the present study, 43 pairs of human RCC and neighboring normal renal tissues were examined for protein expression and immunohistochemistry examination of RPS20. Lentiviral transduction was also employed to create RPS20 knockdown cell lines for downstream cellular experiments. MTT, flow cytometry, wound healing, colony formation and invasion assays were used to examine how RPS20 affected kidney renal clear cell carcinoma (KIRC) cell behavior. Western blotting was used to detect cycle‑related proteins (CDK4 and cyclin D1), Wnt‑related proteins (N‑cadherin and E‑cadherin) and signaling proteins [phosphorylated (p)‑AKT and p‑ERK]. The functions of RPS20

Indexed as

Carcinoma, Renal CellKidney NeoplasmsCadherinsCyclin D1HumansRibosomal ProteinsCadherinsCyclin D1Ribosomal Proteinsribosomal protein S20cell migrationcell proliferationrenal cell carcinomaribosomal protein S20therapeutic targets

Identifiers

PMID36484407
PMCPMC9773015
OpenAlexW4311582525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.