ArticleZoological research2023
Towards magnetism in pigeon MagR: Iron- and iron-sulfur binding work indispensably and synergistically.
Article in Zoological research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Low magnetic fields stimulate cardiac mitochondrial bioenergetics with a bell-shaped response: Possibly via a radical pair mechanism.Computational and structural biotechnology journal · 2025Article
- The physiology of plants in the context of space exploration.Communications biology · 2024Review
- Filamentous morphology engineering of bacteria by iron metabolism modulation through MagR expression.Synthetic and systems biotechnology · 2024Article
- On the evolutionary trail of MagRs.Zoological research · 2024Article
- Proteins as nanomagnets and magnetoreceptors.Zoological research · 2024Article
- Mitochondrial targeting sequence of magnetoreceptor MagR: More than just targeting.Zoological research · 2024Article
- Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations.Zoological research · 2024Article
- Probing Transcriptional Crosstalk betweenInternational journal of molecular sciences · 2023Article
- Preparation of Iron-Based Sulfides and Their Applications in Biomedical Fields.Biomimetics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to navigate long distances is essential for many animals to locate shelter, food, and breeding grounds. Magnetic sense has evolved in various migratory and homing species to orient them based on the geomagnetic field. A highly conserved iron-sulfur cluster assembly protein IscA is proposed as an animal magnetoreceptor (MagR). Iron-sulfur cluster binding is also suggested to play an essential role in MagR magnetism and is thus critical in animal magnetoreception. In the current study, we provide evidence for distinct iron binding and iron-sulfur cluster binding in MagR in pigeons, an avian species that relies on the geomagnetic field for navigation and homing. Pigeon MagR showed significantly higher total iron content from both iron- and iron-sulfur binding. Y65 in pigeon MagR was shown to directly mediate mononuclear iron binding, and its mutation abolished iron-binding capacity of the protein. Surprisingly, both iron binding and iron-sulfur binding demonstrated synergistic effects, and thus appear to be integral and indispensable to pigeon MagR magnetism. These results not only extend our current understanding of the origin and complexity of MagR magnetism, but also imply a possible molecular explanation for the huge diversity in animal magnetoreception.
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Registered trials
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