Evidence map›Paper›PMID 36484063›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2022

Interventions After First Post-Transplant Cutaneous Squamous Cell Carcinoma: A Proposed Decision Framework.

Matthew J Bottomley, Paul R Massey, Raj Thuraisingham, Alden Doyle, Swati Rao, Kristin P Bibee, Jan Nico Bouwes Bavinck, Anokhi Jambusaria-Pahlajani, Catherine A Harwood

Open access · goldAbstract readReview
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Matthew J BottomleyChinese Academy of Medical Sciences Oxford Institute (CAMS-COI), Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Paul R MasseyCheyenne Skin Clinic, Cheyenne, WY, United States.
Raj ThuraisinghamDepartment of Renal Medicine and Transplantation, Barts Health NHS Trust, London, United Kingdom.
Alden DoyleDepartment of Medicine, University of Virginia, Charlottesville, VA, United States.
Swati RaoDepartment of Medicine, University of Virginia, Charlottesville, VA, United States.
Kristin P BibeeDepartment of Dermatology, School of Medicine, John Hopkins University, Baltimore, MD, United States.
Jan Nico Bouwes BavinckDepartment of Dermatology, Leiden University Medical Centre, Leiden, Netherlands.
Anokhi Jambusaria-PahlajaniDivision of Dermatology, Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, United States.
Catherine A HarwoodCentre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
University of Virginia · USBarts Health NHS Trust · GBCheyenne VA Medical Center · USLeiden University Medical Center · NLNHS Blood and Transplant · GBQueen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (CSCC) is a major cause of morbidity and mortality after organ transplant. Many patients subsequently develop multiple CSCC following a first CSCC, and the risk of metastasis and death is significantly increased compared to the general population. Post-transplant CSCC represents a disease at the interface of dermatology and transplant medicine. Both systemic chemoprevention and modulation of immunosuppression are frequently employed in patients with multiple CSCC, yet there is little consensus on their use after first CSCC to reduce risk of subsequent tumors. While relatively few controlled trials have been undertaken, extrapolation of observational data suggests the most effective interventions may be at the time of first CSCC. We review the need for intervention after a first post-transplant CSCC and evidence for use of various approaches as secondary prevention, before discussing barriers preventing engagement with this approach and finally highlight areas for future research. Close collaboration between specialties to ensure prompt deployment of these interventions after a first CSCC may improve patient outcomes.

Indexed as

Carcinoma, Squamous CellSkin NeoplasmsHumanscancermanagementoutcomesskin cancertransplant

Identifiers

PMID36484063
PMCPMC9722441
OpenAlexW4309524015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.