Evidence map›Paper›PMID 36484057›Full record

ArticlePulmonary circulation2022

Commercial human pulmonary artery endothelial cells have in-vitro behavior that varies by sex.

Katherine Cox-Flaherty, Grayson L Baird, Julie Braza, Brianna D Guarino, Amy Princiotto, Corey E Ventetuolo, Elizabeth O Harrington

Abstract read
In one paragraph

Article in Pulmonary circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katherine Cox-FlahertyDepartments of Medicine and Health Services Policy and Practice, Brown University Providence Rhode Island USA.ORCID https://orcid.org/0000-0003-0974-8341
Grayson L BairdLifespan Hospital System Providence Rhode Island USA.
Julie BrazaVascular Research Laboratory, Providence Veterans Affairs Medical Center Providence Rhode Island USA.
Brianna D GuarinoDepartments of Medicine and Health Services Policy and Practice, Brown University Providence Rhode Island USA.
Amy PrinciottoVascular Research Laboratory, Providence Veterans Affairs Medical Center Providence Rhode Island USA.
Corey E VentetuoloDepartments of Medicine and Health Services Policy and Practice, Brown University Providence Rhode Island USA.
Elizabeth O HarringtonDepartments of Medicine and Health Services Policy and Practice, Brown University Providence Rhode Island USA.

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI CHOUDHARY, GAURAV, HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Brown Respiratory Research Training ProgramT32HL134625 · NHLBI · BROWN UNIVERSITY · PI Elizabeth O Harrington, Sharon Irene Smith Rounds · 2017 to 2026
$5.1M
Effects of DHEA in Pulmonary Hypertension (DiPH)R01HL141268 · NHLBI · RHODE ISLAND HOSPITAL · PI VENTETUOLO, COREY E · 2018 to 2022
$3.7M
NHLBI NIH HHS R01 HL141268NHLBI NIH HHS T32 HL134625NIGMS NIH HHS P20 GM103652
6 · The paper itself

Abstract

It is unknown whether biological sex influences phenotypes of commercially available human pulmonary artery endothelial cells (HPAECs). Ten lots of commercial HPAECs were used (Lonza Biologics; PromoCell). Five (50%) were confirmed to be genotypically male (

Indexed as

culturedendothelial cellshumansin vitro techniquessex characteristics

Identifiers

PMID36484057
PMCPMC9723258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.