Evidence map›Paper›PMID 36483848›Full record

ReviewWorld journal of stem cells2022

Profile of biological characterizations and clinical application of corneal stem/progenitor cells.

Pei-Xi Ying, Min Fu, Chang Huang, Zhi-Hong Li, Qing-Yi Mao, Sheng Fu, Xu-Hui Jia, Yu-Chen Cao, Li-Bing Hong, Li-Yang Cai and 4 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of stem cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Pei-Xi YingDepartment of Ophthalmology, Zhujiang Hospital, The Second Clinical School, Southern Medical University, Guangzhou 510280, Guangdong Province, China.
Min FuDepartment of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China.
Chang HuangEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200030, China.
Zhi-Hong LiDepartment of Cardiology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Lab of Shock and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou 510550, Guangdong Province, China.
Qing-Yi MaoThe Second Clinical School, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
Sheng FuHengyang Medical School, The University of South China, Hengyang 421001, Hunan Province, China.
Xu-Hui JiaThe Second Clinical School, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
Yu-Chen CaoThe Second Clinical School, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
Li-Bing HongThe Second Clinical School, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
Li-Yang CaiThe Second Clinical School, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
Xi GuoMedical College of Rehabilitation, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
Ru-Bing LiuThe Second Clinical School, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
Fan-Ke MengEmergency Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China.
Guo-Guo YiDepartment of Ophthalmology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China. yigg@mail.sysu.edu.cn.
Eye & ENT Hospital of Fudan University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal stem/progenitor cells are typical adult stem/progenitor cells. The human cornea covers the front of the eyeball, which protects the eye from the outside environment while allowing vision. The location and function demand the cornea to maintain its transparency and to continuously renew its epithelial surface by replacing injured or aged cells through a rapid turnover process in which corneal stem/progenitor cells play an important role. Corneal stem/progenitor cells include mainly corneal epithelial stem cells, corneal endothelial cell progenitors and corneal stromal stem cells. Since the discovery of corneal epithelial stem cells (also known as limbal stem cells) in 1971, an increasing number of markers for corneal stem/progenitor cells have been proposed, but there is no consensus regarding the definitive markers for them. Therefore, the identification, isolation and cultivation of these cells remain challenging without a unified approach. In this review, we systematically introduce the profile of biological characterizations, such as anatomy, characteristics, isolation, cultivation and molecular markers, and clinical applications of the three categories of corneal stem/progenitor cells.

Indexed as

BioengineeringCorneal endothelium stem cellsCorneal epithelial stem cellsCorneal stromal stem cellsGene markers

Identifiers

PMID36483848
PMCPMC9724387
OpenAlexW4310084479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.