ArticleFrontiers in bioengineering and biotechnology2022
Nanocellulose coated paper diagnostic to measure glucose concentration in human blood.
Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new generation of rapid, easy to use and robust colorimetric point of care (POC) nanocellulose coated-paper sensors to measure glucose concentration in blood is presented in this study. The cellulose gel containing the enzyme with co-additive is coated and dried onto a paper substrate. Nanocellulose gel is used to store, immobilize and stabilize enzymes within its structure to prolong enzyme function and enhance its availability. Here, we immobilize glucose oxidase within the gel structure to produce a simple colorimetric blood glucose sensor. Increase in blood glucose concentration increases the concentration of reaction product which decreases the system pH detected by the pH indicative dye entrapped in the nanocellulose gel. The sensor produces a color change from red to orange as pH decreases due to the enzymatic reaction of glucose into gluconic acid and hydrogen peroxide. This sensor can measure glucose concentrations of 7-13 mM (medical range for diabetes control) at temperatures of 4°C-40°C. Stability tests confirm that no denaturation of enzyme occurs by measuring enzyme activity after 4 weeks. A prototype device is designed to instantly measure the glucose concentration from blood in a two steps process: 1) red blood cell separation and 2) quantification of glucose by color change. This study demonstrates nanocellulose sensor as an economical, robust, and sensitive diagnostic technology platform for a broad spectrum of diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.