Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care.

Krishnamachari Srinivasan, Luke Joshua Salazar, Elsa Heylen, Maria L Ekstrand

Abstract read

In one paragraph

Article in International journal of noncommunicable diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Krishnamachari SrinivasanDepartment of Psychiatry, St. John's Medical College.

Luke Joshua SalazarDepartment of Psychiatry, St. John's Medical College.

Elsa HeylenDepartment of Medicine, Division of Prevention Sciences, University of California, San Francisco, California, USA.

Maria L EkstrandDivision of Mental Health and Neurosciences, St. John's Research Institute, Bengaluru, Karnataka, India.

Funding

Improving Mental Health through Integration with Primary Care in Rural KarnatakaR01MH100311 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EKSTRAND, MARIA L., KRISHNAMACHARI, SRINIVASAN · 2014 to 2018

$1.9M

NIMH NIH HHS R01 MH100311

6 · The paper itself

Abstract

We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-randomized controlled trial designed to evaluate the effects of using a collaborative care model to integrate screening and treatment of primary health center patients. tHcy was assayed at baseline, and depression severity scores were assessed using the Patient Health Questionnaire (PHQ-9) 6 months later. There was no difference in the mean PHQ-9 score between those with (mean PHQ = 7.4) and without (mean PHQ = 7.6) elevated tHcy levels (

Indexed as

Depressionhomocysteineprimary health care

Identifiers

PMID36483766

PMCPMC9728592

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.