Evidence map›Paper›PMID 36483751›Full record

ArticleInternational journal of bioprinting2022

Extrusion Printed Silk Fibroin Scaffolds with Post-mineralized Calcium Phosphate as a Bone Structural Material.

Ruya Shi, Xingxing Cai, Guanping He, Juan Guan, Yuzeng Liu, Hongyi Lu, Zhinan Mao, Yan Li, Hongbo Guo, Yong Hai

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In one paragraph

Article in International journal of bioprinting, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruya ShiSchool of Materials Science and Engineering, Beihang University, Beijing 100083, China.
Xingxing CaiSchool of Materials Science and Engineering, Beihang University, Beijing 100083, China.
Guanping HeDepartment of Orthopedics, Capital Medical University Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Juan GuanSchool of Materials Science and Engineering, Beihang University, Beijing 100083, China.
Yuzeng LiuDepartment of Orthopedics, Capital Medical University Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Hongyi LuDepartment of Orthopedics, Capital Medical University Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Zhinan MaoSchool of Materials Science and Engineering, Beihang University, Beijing 100083, China.
Yan LiSchool of Materials Science and Engineering, Beihang University, Beijing 100083, China.
Hongbo GuoSchool of Materials Science and Engineering, Beihang University, Beijing 100083, China.
Yong HaiDepartment of Orthopedics, Capital Medical University Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial bone materials are of high demand due to the frequent occurrence of bone damage from trauma, disease, and ageing. Three-dimensional (3D) printing can tailor-make structures and implants based on biomaterial inks, rendering personalized bone medicine possible. Herein, we extrusion-printed 3D silk fibroin (SF) scaffolds using mixed inks from SF and sodium alginate (SA), and post-mineralized various calcium phosphates to make hybrid SF scaffolds. The effects of printing conditions and mineralization conditions on the mechanical properties of SF scaffolds were investigated. The SF scaffolds from ~10 wt% SF ink exhibited a compressive modulus of 240 kPa, which was elevated to ~1600 kPa after mineralization, showing a significant reinforcement effect. Importantly, the mineralized SF 3D scaffolds exhibited excellent MC3T3-E1 cell viability and promoted osteogenesis. The work demonstrates a convenient strategy to fabricate SF-based hybrid 3D scaffolds with bone-mimetic components and desirable mechanical properties for bone tissue engineering.

Indexed as

3D-printingHybrid materialMineralizationStructural biomaterial

Identifiers

PMID36483751
PMCPMC9723510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.