Evidence map›Paper›PMID 36483571›Full record

ArticleSouthern African journal of infectious diseases2022

D-dimers in omicron versus delta: A retrospective analysis.

Alon H Shulman, Barry Jacobson, Bradley M Segal, Amber Khan, Jessica Trusler, Lindsay Earlam, Guy Shemesh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Southern African journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Alon H ShulmanDepartment of Haematology and Molecular Medicine, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-3660-0839
Barry JacobsonDepartment of Haematology and Molecular Medicine, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-6981-3112
Bradley M SegalDepartment of Haematology and Molecular Medicine, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-5313-4596
Amber KhanDepartment of Haematology and Molecular Medicine, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-9950-0464
Jessica TruslerClinical Pathology Division, Ampath Laboratories, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-8513-5390
Lindsay EarlamDepartment of Haematology, Lancet Laboratories, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-1939-1721
Guy ShemeshDepartment of Haematology and Molecular Medicine, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-3153-887X
National Health Laboratory Service · ZAUniversity of the Witwatersrand · ZALancet Laboratories · ZAMilpark Hospital · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Infection with SARS-CoV-2 has shown to cause an increase in D-dimers, which correlate with severity and prognosis for in-hospital mortality. The B.1.617.2 (delta) variant is known to cause a raised D-dimer level, with data on D-dimers in the B.1.1.529 (omicron) variant being scarce. Objectives: To determine the effect of age, gender and SARS-CoV-2 variant on the D-dimer in South Africans admitted to tertiary medical centres from May 2021 to December 2021. Method: The study was performed retrospectively on 16 010 adult patients with a SARS-CoV-2 infection. Age, gender, SARS-CoV-2 PCR and D-dimer levels on admission were collected from two national laboratories. Admissions from 01 May 2021 to 31 October 2021 were classified as B.1.617.2, whereas admissions from 01 November 2021 to 23 December 2021 were classified as B.1.1.529 infections. Results: Omicron infections had a median D-dimer level of 0.54 µg/mL (95% CI: 0.32, 1.08, Conclusion: Infection with the B.1.1.529 variant, compared with B.1.617.2 variant, had significantly lower D-dimer levels, with age being a more significant predictor of D-dimer levels, than gender and SARS-CoV-2 variant of infection. Contribution: This study provides novel insight into the hypercoagulable impact of various SARS-CoV-2 variants, which can guide the management of patients.

Indexed as

B.1.1.529B.1.617.2D-dimerdeltaomicronSARS-CoV-2

Identifiers

PMID36483571
PMCPMC9724093
OpenAlexW4311025825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.