Evidence map›Paper›PMID 36483128›Full record

ArticleObesity science & practice2022

Association between fat-infiltrated axillary lymph nodes on screening mammography and cardiometabolic disease.

Qingyuan Song, Roberta M diFlorio-Alexander, Sohum D Patel, Ryan T Sieberg, Michael J Margron, Saif M Ansari, Margaret R Karagas, Todd A Mackenzie, Saeed Hassanpour

Open access · goldAbstract read
In one paragraph

Article in Obesity science & practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Qingyuan SongDepartment of Biomedical Data Science Dartmouth College Lebanon New Hampshire USA.
Roberta M diFlorio-AlexanderDepartment of Radiology Dartmouth-Hitchcock Medical Center Lebanon New Hampshire USA.
Sohum D PatelDepartment of Radiology Dartmouth-Hitchcock Medical Center Lebanon New Hampshire USA.
Ryan T SiebergDepartment of Radiology Dartmouth-Hitchcock Medical Center Lebanon New Hampshire USA.
Michael J MargronDepartment of Radiology Dartmouth-Hitchcock Medical Center Lebanon New Hampshire USA.
Saif M AnsariDepartment of Radiology Dartmouth-Hitchcock Medical Center Lebanon New Hampshire USA.
Margaret R KaragasDepartment of Epidemiology Dartmouth College Lebanon New Hampshire USA.
Todd A MackenzieDepartment of Biomedical Data Science Dartmouth College Lebanon New Hampshire USA.
Saeed HassanpourDepartment of Biomedical Data Science Dartmouth College Lebanon New Hampshire USA.ORCID https://orcid.org/0000-0001-9460-6414
Dartmouth–Hitchcock Medical Center · USDartmouth College · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2013 to 2022
$23.7M
Clinicopathologic and Genetic Profiling through Machine Learning and Natural Language Processing for Precision Lung Cancer ManagementR01CA249758 · NCI · DARTMOUTH COLLEGE · PI HASSANPOUR, SAEED · 2019 to 2022
$1.5M
Improving Colorectal Cancer Screening and Risk Assessment through Deep Learning on Medical Images and RecordsR01LM012837 · NLM · DARTMOUTH COLLEGE · PI HASSANPOUR, SAEED · 2019 to 2022
$1.4M
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA249758NIGMS NIH HHS P20 GM104416NLM NIH HHS R01 LM012837
6 · The paper itself

Abstract

Objective: Ectopic fat deposition within and around organs is a stronger predictor of cardiometabolic disease status than body mass index (BMI). Fat deposition within the lymphatic system is poorly understood. This study examined the association between the prevalence of cardiometabolic disease and ectopic fat deposition within axillary lymph nodes (LNs) visualized on screening mammograms. Methods: A cross-sectional study was conducted on 834 women presenting for full-field digital screening mammography. The status of fat-infiltrated LNs was assessed based on the size and morphology of axillary LNs from screening mammograms. The prevalence of cardiometabolic disease was retrieved from the electronic medical records, including type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, high blood glucose, cardiovascular disease, stroke, and non-alcoholic fatty liver disease. Results: Fat-infiltrated axillary LNs were associated with a high prevalence of T2DM among all women (adjusted odds ratio: 3.92, 95% CI: [2.40, 6.60], Conclusion: Fat-infiltrated axillary LNs visualized on screening mammograms were associated with the prevalence of T2DM. If further validated, fat-infiltrated axillary LNs may represent a novel imaging biomarker of T2DM in women undergoing screening mammography.

Indexed as

cardiometabolic diseaseectopic fatlymph nodescreening mammography

Identifiers

PMID36483128
PMCPMC9722459
OpenAlexW4225384207

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.