Evidence map›Paper›PMID 36483110›Full record

ArticleVirus evolution2022

Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways.

Shefali Banerjee, Cathy Smith, Adam P Geballe, Stefan Rothenburg, Jacob O Kitzman, Greg Brennan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Shefali BanerjeeDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
Cathy SmithDepartments of Microbiology and Medicine, University of Washington, Seattle, WA 98195, USA.ORCID https://orcid.org/0000-0003-1518-9320
Adam P GeballeDepartments of Human Genetics and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Stefan RothenburgDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.ORCID https://orcid.org/0000-0002-2525-8230
Jacob O KitzmanDepartments of Microbiology and Medicine, University of Washington, Seattle, WA 98195, USA.
Greg BrennanDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.ORCID https://orcid.org/0000-0002-4339-9045
University of California, Davis · USUniversity of Washington · USUniversity of Michigan · US

Funding

Roles of Experimentally Evolved Vaccinia Mutations in Antagonizing Cell DefensesR21AI109340 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GEBALLE, ADAM P. · 2014 to 2015
$484k
Molecular and evolutionary mechanisms of poxviral adaptation to new speciesR21AI135257 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BRENNAN, GREGORY JASON, KITZMAN, JACOB OTTO · 2019 to 2020
$446k
NIAID NIH HHS R21 AI109340NIAID NIH HHS R21 AI135257
6 · The paper itself

Abstract

Cross-species spillover events are responsible for many of the pandemics in human history including COVID-19; however, the evolutionary mechanisms that enable these events are poorly understood. We have previously modeled this process using a chimeric vaccinia virus expressing the rhesus cytomegalovirus-derived protein kinase R (PKR) antagonist RhTRS1 in place of its native PKR antagonists: E3L and K3L (VACVΔEΔK + RhTRS1). Using this virus, we demonstrated that gene amplification of

Indexed as

cross-species adaptationgene duplicationPKRRhTRS1RNase Lvaccinia virus

Identifiers

PMID36483110
PMCPMC9724558
OpenAlexW4309183063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.