Evidence map›Paper›PMID 36482997›Full record

ReviewFrontiers in endocrinology2022

The role of Nrf2 in periodontal disease by regulating lipid peroxidation, inflammation and apoptosis.

Fengyu Ma, Shangdie Luo, Chunting Lu, Xinrong Jiang, Kexiao Chen, Jianwen Deng, Shuyuan Ma, Zejian Li

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fengyu MaDepartment of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Shangdie LuoDepartment of Orthodontics, Huizhou Stomatological Hospital, Huizhou, Guangdong, China.
Chunting LuScience and Education Office, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.
Xinrong JiangDepartment of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Kexiao ChenDepartment of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Jianwen DengDepartment of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Shuyuan MaDepartment of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Zejian LiDepartment of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
First Affiliated Hospital of Jinan University · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear factor E2-related factor 2(Nrf2) is a transcription factor that mainly regulates oxidative stress in the body. It initiates the expression of several downstream antioxidants, anti-inflammatory proteins and detoxification enzymes through the Kelch-like ECH-associating protein 1 (Keap1) -nuclear factor E2-related factor 2(Nrf2) -antioxidant response element (ARE) signaling pathway. Its anti-apoptosis, anti-oxidative stress and anti-inflammatory effects have gradually become the focus of periodontal disease research in recent years. In this paper, the structure and function of Nrf2 pathway and its mechanism of action in the treatment of periodontitis in recent years were analyzed and summarized, so as to further clarify the relationship between Nrf2 pathway and oxidative stress in the occurrence and development of periodontitis, and to provide ideas for the development of new treatment drugs targeting Nrf2 pathway.

Indexed as

NF-E2-Related Factor 2Periodontal DiseasesAnti-Inflammatory AgentsHumansKelch-Like ECH-Associated Protein 1Lipid PeroxidationAnti-Inflammatory AgentsKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2apoptosisbone homeostasislipid peroxidationNrf2periodontal disease

Identifiers

PMID36482997
PMCPMC9723463
OpenAlexW4309717657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.