ArticleInternational psychogeriatrics2023
Loneliness and risk of all-cause, Alzheimer's, vascular, and frontotemporal dementia: a prospective study of 492,322 individuals over 15 years.
Article in International psychogeriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Loneliness as an Interface Between Alzheimer's Disease and Suicidal Behaviour: A Systematic Review, Meta-Analysis and Meta-Analytic Factor Analysis.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Pooled it
- Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers' Brain Health: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Pooled it
- Public Health Policy Responses to Population Aging in Mexico: A Rights-Based and Socio-Legal Approach.Healthcare (Basel, Switzerland) · 2026Review
- Is my loneliness killing me? Effects of loneliness and social isolation on transitions between cognitive status categories and death.Journal of personality and social psychology · 2026Article
- The social environment and cognitive aging over the life course: laying out critical concepts and research gaps.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.Nature communications · 2026Article
- Socio-emotional well-being is associated with cognitive function and informant-rated cognitive decline: Results from the Harmonized Cognitive Assessment Protocol in Europe.Journal of the International Neuropsychological Society : JINS · 2026Article
- Neighborhood social cohesion and Alzheimer's disease dementia risk in South Asians in the United States.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Loneliness and Biomarkers of Alzheimer's Disease, Axonal Damage, and Astrogliosis: A Coordinated Analysis of Two Longitudinal Cohorts.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Ameliorating loneliness through Cognitive Stimulation Therapy and the role of baseline loneliness in predicting cognitive, behavioural and psychological benefits in people with dementia.Frontiers in psychology · 2025Article
- Baseline characterization of dementia cases from a reference center in Recife, Northeast Brazil.Dementia & neuropsychologia · 2025Article
- A Meta-analysis of Loneliness and Risk of Dementia using Longitudinal Data from >600,000 Individuals.Nature. Mental health · 2024Article
- Loneliness, cerebrovascular and Alzheimer's disease pathology, and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Life Events and Incident Dementia: A Prospective Study of 493,787 Individuals Over 16 Years.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions.Annals of neurology · 2024Review
- Contributions of loneliness to cognitive impairment and dementia in older adults are independent of other risk factors and Alzheimer's pathology: a narrative review.Frontiers in human neuroscience · 2024Review
- Unraveling the dynamics of loneliness and cognition in late life: a cross-lagged panel model.Frontiers in public health · 2024Article
- Psycho-social and health predictors of loneliness in older primary care patients and mediating mechanisms linking comorbidities and loneliness.BMC geriatrics · 2023Article
- The Association between Levels of Physical Activity and Lifestyle, Life Expectancy, and Quality of Life in Patients with Alzheimer's Disease.Journal of clinical medicine · 2023Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesThis study examined the association between loneliness and risk of incident all-cause dementia and whether the association extends to specific causes of dementia.
designLongitudinal.
settingCommunity.
participantsParticipants were from the UK Biobank (
interventionNone. MEASUREMENTS: Loneliness was measured with a standard item. The diagnosis of dementia was derived from health and death records, which included all-cause dementia and the specific diagnoses of Alzheimer's disease (AD), vascular dementia (VD), and frontotemporal dementia (FTD), over 15 years of follow-up.
resultsFeeling lonely was associated with a nearly 60% increased risk of all-cause dementia (HR = 1.59, 95% CI = 1.51-1.65;
conclusionLoneliness is associated with increased risk of multiple types of dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.