ArticleDeutsches Arzteblatt international2022
Modern Principles of Diagnosis and Treatment in Complex Regional Pain Syndrome.
Article in Deutsches Arzteblatt international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Cognitive Function in Patients With Complex Regional Pain Syndrome (CRPS).European journal of pain (London, England) · 2025Trial
- Hyperbaric oxygen therapy: a novel treatment option in complex regional pain syndrome and other chronic pain conditions.Medical gas research · 2026Article
- Rehabilitation outcomes in patients with complex regional pain syndrome of the ankle-foot complex: a single-center observational study.BMC musculoskeletal disorders · 2026Observational
- Incidence proportion of complex regional pain syndrome (CRPS) after distal radius fracture: a population-based register study.Acta orthopaedica · 2026Article
- Complex regional pain syndrome in a living kidney donor.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Review
- Identifying recommendations to improve therapy-led management of complex regional pain syndrome in England.British journal of pain · 2025Article
- Diagnostic Criteria and Technical Evaluation of Complex Regional Pain Syndrome: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- [Fractures of the finger and metacarpal bones II-V : Diagnostics and treatment].Unfallchirurgie (Heidelberg, Germany) · 2025Review
- Efficacy of Immunotherapy for Complex Regional Pain Syndrome: A Narrative Review.Current pain and headache reports · 2025Review
- Complex Regional Pain Syndrome in Cancer Cases: Current Knowledge and Perspectives.International medical case reports journal · 2024Article
- The Effectiveness of Hyperbaric Oxygen Treatment in Patients with Complex Regional Pain Syndrome: A Retrospective Case series.International journal of medical sciences · 2024Article
- The Treatment of Closed Finger and Metacarpal Fractures.Deutsches Arzteblatt international · 2023Review
- Additions Required.Deutsches Arzteblatt international · 2023Article
- Complex Pathophysiology and Differentiated Therapy.Deutsches Arzteblatt international · 2023Article
- In Reply.Deutsches Arzteblatt international · 2023Article
- Confusing and Substantially Overinterpreted.Deutsches Arzteblatt international · 2023Article
- Effect and mechanisms of exercise for complex regional pain syndrome.Frontiers in molecular neuroscience · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBackground: Complex regional pain syndrome (CRPS) is a relatively common complication, occurring in 5% of cases after injury or surgery, particularly in the limbs. The incidence of CPRS is around 5-26/100 000. The latest revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11) now categorizes CRPS as a primary pain condition of multifactorial origin, rather than a disease of the skeletal system or the autonomic nervous system.
methodsMethod: Based on a selective search of the literature, we summarize current principles for the diagnosis and treatment of CRPS.
resultsResults: Regional findings in CRPS are accompanied by systemic symptoms, especially by neurocognitive disorders of body perception and of symptom processing. The therapeutic focus is shifting from predominantly passive peripheral measures to early active treatments acting both centrally and peripherally. The treatment is centered on physiotherapy and occupational therapy to improve sensory perception, strength, (fine) motor skills, and sensorimotor integration/ body perception. This is supported by stepped psychological interventions to reduce anxiety and avoidance behavior, medication to decrease inflammation and pain, passive physical measures for reduction of edema and of pain, and medical aids to improve functioning in daily life. Interventional procedures should be limited to exceptional cases and only be performed in specialized centers. Spinal cord and dorsal root ganglion stimulation, respectively, are the interventions with the best evidence.
conclusionConclusion: The modern principles for the diagnosis and treatment of CRPS consider both, physiological and psychological mechanisms, with the primary goal of restoring function and participation. More research is needed to strengthen the evidence base in this field.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.