Evidence map›Paper›PMID 36482748›Full record

ReviewDeutsches Arzteblatt international2023

Refeeding Syndrome.

Lara Heuft, Jenny Voigt, Lars Selig, Michael Stumvoll, Haiko Schlögl, Thorsten Kaiser

Open access · greenAbstract readReview
In one paragraph

Review in Deutsches Arzteblatt international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Refeeding syndrome in head and neck cancers: a risk in the prehabilitation of patients?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. One Page in the History of Starvation and Refeeding.Rambam Maimonides medical journal · 2024
    Review
  13. Gut Microbiome Changes in Anorexia Nervosa: A Comprehensive Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
  14. Article
  15. Article
  16. In Reply.Deutsches Arzteblatt international · 2023
    Article
  17. An Additional Symptom.Deutsches Arzteblatt international · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lara HeuftInstitut für Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of LeipzigMedical Center, Leipzig, GermanyInstitute for Human Genetics, University of Leipzig Medical Center, Leipzig, GermanyDepartment of Endocrinology, Nephrology, Rheumatology, Division of Endocrinology, University ofLeipzig Medical Center, Leipzig, GermanyDepartment of Endocrinology, Nephrology, Rheumatology, Special Division of Endocrinology,University of Leipzig Medical Center, Leipzig, Germany Klinik und Poliklinik für Endokrinologie,Nephrologie, Rheumatologie, Spezialbereich Ernährungs medizin, Universitätsklinikum LeipzigHelmholtz Institute for Metabolic, Obesity, and Vascular Research (HI-MAG), Helmholtz ZentrumMünchen, University of Leipzig, and the University Hospital Leipzig, Leipzig, GermanyInstitute for Laboratory Medicine, Microbiology, Clinical Pathology, and Pathobiochemistry, UniversityHospital Lippe, Detmold, Germany.
Jenny Voigt
Lars Selig
Michael Stumvoll
Haiko Schlögl
Thorsten Kaiser
University Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRefeeding syndrome (RFS) can occur in malnourished patients when normal, enteral, or parenteral feeding is resumed. The syndrome often goes unrecognized and may, in the most severe cases, result in death. The diagnosis of RFS can be crucially facilitated by the use of clinical decision support systems (CDSS).

methodsThe literature in PubMed was searched for current treatment recommendations, randomized intervention studies, and publications on RFS and CDSS. We also took account of insights gained from the development and implementation of our own CDSS for the diagnosis of RFS.

resultsThe identification of high-risk patients and the recognition of manifest RFS is clinically challenging due to the syndrome's unspecific symptoms and physicians' lack of awareness of the risk of this condition. The literature shows that compared to patients without RFS, malnourished patients with RFS have significantly greater 6-month mortality (odds ratio 1.54, 95% confidence interval: [1.04; 2.28]) and an elevated risk of admission to intensive care (odds ratio 2.71 [1.01; 7.27]). In a prospective testing program, use of our own CDSS led to correct diagnosis in two thirds of cases.

conclusionRFS is difficult to detect and represents a high risk to the patients affected. Appropriate CDSS can identify such patients and ensure proper professional care.

Indexed as

MalnutritionRefeeding SyndromeHospitalizationHumansOdds RatioProspective Studies

Identifiers

PMID36482748
PMCPMC10132284
OpenAlexW4311204582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.