Evidence map›Paper›PMID 36482698›Full record

ReviewDrug delivery2023

Immunomodulatory nano-preparations for rheumatoid arthritis.

Chenglong Li, Yangyun Han, Xianjin Luo, Can Qian, Yang Li, Huaiyu Su, Guangshen Du

Open access · goldAbstract readReview
In one paragraph

Review in Drug delivery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Chenglong LiDepartment of Pharmacy, The People's Hospital of Deyang City, Deyang, P.R. China.ORCID 0000-0001-8171-6227
Yangyun HanDepartment of Neurosurgery, The People's Hospital of Deyang City, Deyang, P.R. China.
Xianjin LuoPharmaceutical Biotechnology, Center for System-based Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.
Can QianDepartment of Pharmacy, The People's Hospital of Deyang City, Deyang, P.R. China.
Yang LiDepartment of Pharmacy, The People's Hospital of Deyang City, Deyang, P.R. China.
Huaiyu SuDepartment of Pharmacy, The People's Hospital of Deyang City, Deyang, P.R. China.
Guangshen DuKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, P.R. China.
Fuyang City People's Hospital · CNDeyang Stomatological Hospital · CNLudwig-Maximilians-Universität München · DESichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease (AD) caused by the aberrant attack of the immune system on its own joint tissues. Genetic and environmental factors are the main reasons of immune system impairment and high incidence of RA. Although there are medications on the market that lessen disease activity, there is no known cure for RA, and patients are at risk in varying degrees of systemic immunosuppression. By transporting (encapsulating or surface binding) RA-related self-antigens, nucleic acids, immunomodulators, or cytokines, tolerogenic nanoparticles-also known as immunomodulatory nano-preparations-have the potential to gently regulate local immune responses and ultimately induce antigen-specific immune tolerance. We review the recent advances in immunomodulatory nano-preparations for delivering self-antigen or self-antigen plus immunomodulator, simulating apoptotic cell avatars

Indexed as

Arthritis, RheumatoidImmunityAutoantigensHumansAutoantigensantigen-specific immune toleranceimmunomodulatorImmunomodulatory nano-preparationsrheumatoid arthritisself-antigen

Identifiers

PMID36482698
PMCPMC9744217
OpenAlexW4311577024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.