ArticleInfectious diseases of poverty2022
First record of the human infection of Brucella melitensis in Kyrgyzstan: evidence from whole-genome sequencing-based analysis.
Article in Infectious diseases of poverty, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Molecular Epidemiology ofVeterinary sciences · 2025Article
- Study of epidemiological and molecular characteristics of Brucella strains circulating in Kazakhstan.Veterinary research communications · 2025Article
- The continuous expansion and spread of human brucellosis in the Xinjiang Uygur Autonomous Region: evidence from epidemiological and strains' genotyping-based analysis.BMC microbiology · 2025Article
- Genetic diversity atlas of Brucella melitensis strains from Sichuan Province, China.BMC microbiology · 2025Article
- Epidemiological, clinical, and laboratory characteristics of 581 human brucellosis cases in Xinjiang, China.Frontiers in microbiology · 2025Article
- Molecular epidemiology ofFrontiers in microbiology · 2025Article
- Molecular epidemiology of brucellosis in Asia: insights from genotyping analyses.Veterinary research communications · 2024Review
- Rapid Identification ofMicroorganisms · 2024Article
- Epidemiological changes and molecular characteristics ofFrontiers in microbiology · 2024Article
- MultipleFrontiers in cellular and infection microbiology · 2024Article
- Brucellosis outbreak in a remote village in northwestern Tajikistan in 2023: a matched case-control study.Frontiers in epidemiology · 2024Article
- Original and introduced lineages co-driving the persistence ofFrontiers in public health · 2023Article
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Abstract
backgroundBrucellosis, a zoonosis mainly transmitted by consumption of unpasteurized dairy products as well as direct contact with infected animals, is endemic in Kyrgyzstan. However, Brucella species in humans have not been investigated and the origin of the disease remains poorly known in wide parts of Сentral Asia. Thus, molecular characterization of the circulating strains is a critical first step in understanding Brucella diversity in the country.
methodsIn this study, isolates were collected from patients with suspected brucellosis from different regions in Kyrgyzstan between 2019 and 2020. The detection and identification of Brucella was carried out by Bruce-ladder PCR. Next generation sequencing was used to sequence the 89 Brucella isolates, which were genotyped by cgSNP and cgMLST to identify epidemiological connection between Brucella isolates as well as placing them in the context of the global Brucella phylogeny.
resultsThe Brucella strains isolated from all regions of Kyrgyzstan were identified as B. melitensis. Based on cgSNP analysis, 18 sequence types were differentiated. The highest numbers of different sequence types were found in Batken (n = 8), Osh (n = 8) and Jalal-Abad (n = 6) oblasts. According to cgSNP and cgMLST analyses, different B. melitensis lineages circulate in Kyrgyzstan, all of them belonging to the Eastern Mediterranean group of the global Brucella phylogeny with the highest similarity to strains from Turkmenistan, Iran and Turkey.
conclusionIn the present study, B. melitensis was identified as a causative agent of human brucellosis in Kyrgyzstan and different lineages could be identified. Since this study focused on isolates of human origin, the identity of Brucella species and lineages circulating among animal populations remains elusive. Implementing culture techniques and use of most recent molecular, bioinformatic and epidemiological tools are needed to set up a One Health approach to combat brucellosis in Kyrgyzstan. Further, other Сentral Asian countries need to take part in this effort as brucellosis is a transboundary disease in these regions.
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