ArticleThe journal of headache and pain2022
Cerebral perfusion variance in new daily persistent headache and chronic migraine: an arterial spin-labeled MR imaging study.
Article in The journal of headache and pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Assessment of Cerebral Perfusion Asymmetry in Chronic Migraine Patients Using Intravoxel Incoherent Motion (IVIM)-Derived Pseudodiffusion Coefficient and Perfusion Fraction.NMR in biomedicine · 2026Article
- Pediatric New Daily Persistent Headache: Integrating Novel Research Methods to Support and Delineate Evolving Clinical Phenotypes.Children (Basel, Switzerland) · 2026Article
- Abnormal lymphatic system function in patients with chronic neck and shoulder pain: neuroimaging evidence from DTI-ALPS.Frontiers in molecular neuroscience · 2026Article
- Hallmarks of primary headache: part 4 - rare headache syndromes.The journal of headache and pain · 2025Review
- Abnormal brain iron deposition in patients with new daily persistent headache: a prospective quantitative susceptibility mapping study.The journal of headache and pain · 2025Article
- Changes of Basilar Artery in Patients With Migraine: A Case-Control Study Based on 3T MRI.Brain and behavior · 2025Article
- Article
- Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray in new daily persistent headache: a magnetic resonance spectroscopy study.The journal of headache and pain · 2024Article
- Perfusion imaging by arterial spin labeling in migraine: A literature review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study.The journal of headache and pain · 2024Article
- Altered functional connectivity of brainstem nuclei in new daily persistent headache: Evidence from resting-state functional magnetic resonance imaging.CNS neuroscience & therapeutics · 2024Article
- Mapping brain functional networks topological characteristics in new daily persistent headache: a magnetoencephalography study.The journal of headache and pain · 2023Article
- Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space.The journal of headache and pain · 2023Article
- Auto-Classification of Parkinson's Disease with Different Motor Subtypes Using Arterial Spin Labelling MRI Based on Machine Learning.Brain sciences · 2023Article
- Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study.The journal of headache and pain · 2023Article
- New Daily Persistent Headache (NDPH): Unraveling the Complexities of Diagnosis, Pathophysiology, and Treatment.Current pain and headache reports · 2023Review
- Arterial spin labeling MRI applied to migraine: current insights and future perspectives.The journal of headache and pain · 2023Review
- Mapping the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study.The journal of headache and pain · 2023Article
- Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI.The journal of headache and pain · 2023Article
- Alterations in regional homogeneity and multiple frequency amplitudes of low-frequency fluctuation in patients with new daily persistent headache: a resting-state functional magnetic resonance imaging study.The journal of headache and pain · 2023Article
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeNew daily persistent headache (NDPH) and chronic migraine (CM) are two different types of headaches that might involve vascular dysregulation. There is still a lack of clarity about altered brain perfusion in NDPH and CM. This study aimed to investigate the cerebral perfusion variances of NDPH and CM using multi-delay pseudo-continuous arterial spin-labeled magnetic resonance imaging (pCASL-MRI).
methodsFifteen patients with NDPH, 18 patients with CM, and 15 age- and sex-matched healthy controls (HCs) were included. All participants underwent 3D multi-delay pCASL-MRI to obtain cerebral perfusion data, including arrival-time-corrected cerebral blood flow (CBF) and arterial cerebral blood volume (aCBV). The automated anatomical labeling atlas 3 (AAL3) was used to parcellate 170 brain regions. The CBF and aCBV values in each brain region were compared among the three groups. Correlation analyses between cerebral perfusion parameters and clinical variables were performed.
resultsCompared with HC participants, patients with NDPH were found to have decreased CBF and aCBV values in multiple regions in the right hemisphere, including the right posterior orbital gyrus (OFCpost.R), right middle occipital gyrus (MOG.R), and ventral anterior nucleus of right thalamus (tVA.R), while patients with CM showed increased CBF and aCBV values presenting in the ventral lateral nucleus of left thalamus (tVL.L) and right thalamus (tVL.R) compared with HCs (all p < 0.05). In patients with NDPH, after age and sex adjustment, the increased aCBV values of IFGorb. R were positively correlated with GAD-7 scores; and the increased CBF and aCBV values of tVA.R were positively correlated with disease duration.
conclusionThe multi-delay pCASL technique can detect cerebral perfusion variation in patients with NDPH and CM. The cerebral perfusion changes may suggest different variations between NDPH and CM, which might provide hemodynamic evidence of these two types of primary headaches.
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