Evidence map›Paper›PMID 36482188›Full record

Trial reportBritish journal of cancer2023

Efficacy and toxicity of primary re-irradiation for malignant spinal cord compression based on radiobiological modelling: a phase II clinical trial.

Neil D Wallace, Mary T Dunne, Orla McArdle, Cormac Small, Imelda Parker, Aoife M Shannon, Angela Clayton-Lea, Michael Parker, Conor D Collins, John G Armstrong and 9 more

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00974168 (A Phase II Trial Evaluating the Efficacy of a Radio-Biological Based Re-Irradiation Strategy for Patients With Malignant Spinal Cord Compression), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00974168 phase2completednot on this map

A Phase II Trial Evaluating the Efficacy of a Radio-Biological Based Re-Irradiation Strategy for Patients With Malignant Spinal Cord Compression

TypeinterventionalSponsorCancer Trials IrelandRan2007 to 2018Enrolled22ConditionsPain, Radiation Toxicity, Spinal Cord Compression, Unspecified Adult Solid Tumor, Protocol SpecificArmsCumulative BED ≤ 100, Cumulative BED ≤ 130 Gy2
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Neil D WallaceSt Luke's Radiation Oncology Network, Dublin, Ireland.ORCID http://orcid.org/0000-0002-0109-3996
Mary T DunneSt Luke's Radiation Oncology Network, Dublin, Ireland. mary.dunne@slh.ie.ORCID http://orcid.org/0000-0002-3723-6311
Orla McArdleSt Luke's Radiation Oncology Network, Dublin, Ireland.
Cormac SmallUniversity Hospital Galway, Galway, Ireland.
Imelda ParkerCancer Trials Ireland (formerly All-Ireland Cooperative Oncology Research Group (ICORG)), Dublin, Ireland.
Aoife M ShannonCancer Trials Ireland (formerly All-Ireland Cooperative Oncology Research Group (ICORG)), Dublin, Ireland.
Angela Clayton-LeaSt Luke's Radiation Oncology Network, Dublin, Ireland.
Michael ParkerStatistics and Data Management Office for Cancer Trials Ireland (formerly ICORG), Clinical Research Support Centre, Belfast, Ireland.
Conor D CollinsSt Luke's Radiation Oncology Network, Dublin, Ireland.
John G ArmstrongSt Luke's Radiation Oncology Network, Dublin, Ireland.
Charles GillhamSt Luke's Radiation Oncology Network, Dublin, Ireland.
Jerome CoffeySt Luke's Radiation Oncology Network, Dublin, Ireland.
David FitzpatrickSt Luke's Radiation Oncology Network, Dublin, Ireland.
Osama SalibSt Luke's Radiation Oncology Network, Dublin, Ireland.
Michael MoriartySt Luke's Radiation Oncology Network, Dublin, Ireland.
Michael R StevensonStatistics and Data Management Office for Cancer Trials Ireland (formerly ICORG), Clinical Research Support Centre, Belfast, Ireland.
Alberto Alvarez-IglesiasThe HRB Clinical Research Facility, Galway, Ireland.
Michael McCagueThe HRB Clinical Research Facility, Galway, Ireland.
Pierre G ThirionSt Luke's Radiation Oncology Network, Dublin, Ireland.
Cancer Trials Ireland · IEThe US Oncology Network · USTrinity College Dublin · IEUniversity Hospital Galway · IE

Funding

Health Research Board (HRB) 2016 HRB/CTIHealth Research Board (HRB) CCT/06/09Health Research Board (HRB) ICORG/2012Health Research Board (HRB) ICORGH/2009
6 · The paper itself

Abstract

backgroundThe efficacy and safety of primary re-irradiation for MSCC are not known. Our aim was to establish the efficacy and safety of biologically effective dose-based re-irradiation.

methodsPatients presenting with MSCC at a previously irradiated spine segment, and not proceeding with surgical decompression, were eligible. A 3 Gray per fraction experimental schedule (minimum 18 Gy/6 fractions, maximum 30 Gy/10 fractions) was used, delivering a maximum cumulative spinal dose of 100 Gy

resultsTwenty-two patients were enroled, of whom eleven were evaluable for the primary outcome. Nine of eleven (81.8%) had stable or improved Tomita scores at 5 weeks. One of eight (12.5%) evaluable for late toxicity developed RIM.

conclusionsRe-irradiation is an efficacious treatment for MSCC. There is a risk of RIM with a cumulative dose of 120 Gy CLINICAL

trial registrationCancer Trials Ireland (ICORG 07-11); NCT00974168.

Indexed as

Radiation InjuriesRe-IrradiationSpinal Cord CompressionSpinal Cord NeoplasmsDose Fractionation, RadiationHumansRadiotherapy DosageTreatment Outcome

Identifiers

PMID36482188
PMCPMC9938159
OpenAlexW4310942474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.