ArticleNature human behaviour2023
A genetically informed Registered Report on adverse childhood experiences and mental health.
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In one paragraph
Article in Nature human behaviour, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 9 pooled it
11.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 9 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Understanding adverse childhood experiences within the first decade of the ABCD study: A systematic review.Developmental cognitive neuroscience · 2026Pooled it
- Associations between five forms of child maltreatment and depression: a multilevel meta-analytic comparison.Psychological medicine · 2026Pooled it
- The Relationship Between School Bullying and Suicide-Related Behaviors Among Sexual Minorities: A Systematic Review and Meta-Analysis.Archives of sexual behavior · 2025Pooled it
- Health effects associated with exposure of children to physical violence, psychological violence and neglect: a Burden of Proof study.Nature human behaviour · 2025Pooled it
- Adverse childhood experiences and suicidality in low-income and middle-income countries: a systematic review and meta-analysis.BMJ global health · 2025Pooled it
- Genetic and environment influences on childhood victimization: a systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- Measuring adversity in the ABCD® Study: systematic review and recommendations for best practices.BMC medical research methodology · 2025Pooled it
- Emotion Regulation, Parenting, and Psychopathology: A Systematic Review.Clinical child and family psychology review · 2024Pooled it
- Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Effects of family genetic risk scores and environmental factors on risk of schizophrenia and bipolar disorder.Molecular psychiatry · 2026Article
- Recreational screen use and internalizing problems from preadolescence to young adulthood in a longitudinal twin cohort with co-twin comparison.Nature human behaviour · 2026Article
- Investigating the impact of early adversity on perceived support from parents and friends in preadolescence: Do genetic predispositions and timing of exposure matter?JCPP advances · 2026Article
- Violent and sexual victimisation and incident anxiety, mood and substance use disorders in childhood and adolescence: a co-sibling study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
- Gene-Environment Interplay Beyond Interactions: Psychosocial Environments Mediate Genetic Effects Underlying Externalizing-Behavior Trajectories.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- The longitudinal association between adverse childhood experiences and persistence of psychotic-like experiences in young people: evidence from the ALSPAC birth cohort.Psychological medicine · 2026Article
- Trajectories of childhood adversity, social welfare dependence in young adulthood, and the mediating role of mental health problems: a Danish population-based cohort study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- The role of rare copy number variants in early-onset depression.JCPP advances · 2026Article
- Exploring genetic confounding of the associations between screen time and depressive symptoms in adolescence and early adulthood.International journal of epidemiology · 2026Article
- The correlation between different types of negative life events and the mental health status of Han ethnic adolescents in Sichuan Province.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 11 institutions in 5 countries.
Jessie R BaldwinDepartment of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK. j.baldwin@ucl.ac.uk.ORCID 0000-0002-5703-5058
Hannah M SallisMRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-4793-6290
Tabea SchoelerDepartment of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK.ORCID 0000-0003-4846-2741
Mark J TaylorDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Alex S F KwongMRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0003-1953-2771
Jorim J TielbeekCNCR, Amsterdam Neuroscience Campus, VU University, Amsterdam, the Netherlands.
Wikus BarkhuizenDepartment of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK.ORCID 0000-0001-5170-1470
Varun WarrierDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4532-8571
Laura D HoweMRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK.
Andrea DaneseSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-8718-5412
Eamon McCroryDepartment of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK.ORCID 0000-0001-5336-5079
Fruhling RijsdijkPsychology Department, Faculty of Social Sciences, Anton de Kom University, Paramaribo, Suriname.
Henrik LarssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6851-3297
Sebastian LundströmGillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-7235-8499
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8949-2587
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-3037-5287
Marcus MunafòMRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-4049-993X
Jean-Baptiste PingaultDepartment of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK.
Karolinska Institutet · SEKing's College London · GBUniversity College London · GBUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity of Bristol · GBAmsterdam Neuroscience · NLAnna Freud Centre · GBAnton de Kom University of Suriname · SRÖrebro University · SEUniversity of Cambridge · GBUniversity of Gothenburg · SE
Funding
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MAdolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5MABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MProspective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2MABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7MABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9MFIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8MABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3MABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7MAdolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7MMedical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/7Medical Research Council MC_UU_00032/4Medical Research Council MR/M020894/1Medical Research Council P005918MRF_ MRF-160-0002-ELP-PINGANIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147Wellcome Trust 215917Wellcome Trust 215917/Z/19/ZWellcome Trust 218641Wellcome Trust 218641/Z/19/Z
Abstract
Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA from 11,407 children from the United Kingdom and the United States to investigate gene-environment correlations and genetic confounding of the associations between ACEs and mental health. Regarding gene-environment correlations, children with higher polygenic scores for mental health problems had a small increase in odds of ACEs. Regarding genetic confounding, elevated risk of mental health problems in children exposed to ACEs was at least partially due to pre-existing genetic risk. However, some ACEs (such as childhood maltreatment and parental mental illness) remained associated with mental health problems independent of genetic confounding. These findings suggest that interventions addressing heritable psychiatric vulnerabilities in children exposed to ACEs may help reduce their risk of mental health problems.
Indexed as
Adverse Childhood ExperiencesMental DisordersChildHumansMental HealthParentsRisk FactorsUnited States
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.