Evidence map›Paper›PMID 36481703›Full record

ArticleJournal of neuroimmunology2023

Brain stem encephalitis is a rare complication of COVID-19.

Marc C Shamier, Yvette S Crijnen, Susanne Bogers, Jeroen W IJpelaar, Juna M de Vries, Mathieu van der Jagt, Jochem K H Spoor, Jan H von der Thüsen, Marco W J Schreurs, Corine H GeurtsvanKessel and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of neuroimmunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Marc C ShamierDepartment of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address: m.shamier@erasmusmc.nl.
Yvette S CrijnenDepartment of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands.
Susanne BogersDepartment of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.
Jeroen W IJpelaarDepartment of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.
Juna M de VriesDepartment of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands.
Mathieu van der JagtDepartment of Intensive Care Adults, Erasmus Medical Center, Rotterdam, the Netherlands.
Jochem K H SpoorDepartment of Neurosurgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Jan H von der ThüsenDepartment of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands.
Marco W J SchreursDepartment of Immunology, Erasmus Medical Center, Rotterdam, the Netherlands.
Corine H GeurtsvanKesselDepartment of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.
Maarten J TitulaerDepartment of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands.
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we describe the clinical phenotype of SARS-CoV-2-related CNS disease and evaluate the SARS-CoV-2 antibody index as a tool to differentiate between a direct (viral) and indirect etiology. Out of >4000 hospitalized patients with COVID-19, we included 13 patients with neurological symptoms with suspicion of neuroinflammation. On clinical grounds, eight were classified as having a possible/probable relationship between neurological symptoms and COVID-19. A clinically distinctive phenotype of brainstem and cerebellar symptoms was seen in 6/8 patients. As we found a positive SARS-CoV-2 antibody index in 3/5 patients, indicating specific intrathecal SARS-CoV-2 IgG production, a direct link with SARS-CoV-2 is likely.

Indexed as

COVID-19EncephalitisAntibodies, ViralBrain StemHumansImmunoglobulin GSARS-CoV-2Antibodies, ViralImmunoglobulin GAntibodiesBrain stemCerebellumCOVID-19Encephalitis

Identifiers

PMID36481703
PMCPMC9701569
OpenAlexW4310262041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.