Evidence map›Paper›PMID 36481593›Full record

ArticleDermatology (Basel, Switzerland)2023

New-Onset Guttate Psoriasis: A Long-Term Follow-Up Study.

Eran Galili, Shir Rubinstein Levy, Ido Tzanani, Oz Segal, Anna Lyakhovitsky, Aviv Barzilai, Sharon Baum

Open access · hybridAbstract read
In one paragraph

Article in Dermatology (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Management of Guttate Psoriasis: A Systematic Review.Journal of cutaneous medicine and surgery
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Eran GaliliDepartment of Dermatology, Tel Aviv University, Tel Aviv, Israel.
Shir Rubinstein LevyDepartment of Dermatology, Tel Aviv University, Tel Aviv, Israel, shirrub1@gmail.com.
Ido TzananiDepartment of Dermatology, Tel Aviv University, Tel Aviv, Israel.
Oz SegalDepartment of Dermatology, Tel Aviv University, Tel Aviv, Israel.
Anna LyakhovitskyDepartment of Dermatology, Tel Aviv University, Tel Aviv, Israel.
Aviv BarzilaiDepartment of Dermatology, Tel Aviv University, Tel Aviv, Israel.
Sharon BaumDepartment of Dermatology, Tel Aviv University, Tel Aviv, Israel.
Tel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGuttate psoriasis (GP), a distinct variant of psoriasis, is more common in children and adolescents. The long-term course of these patients has sparsely been examined, with few studies reporting the rates of relapse, persistence, and further development of the psoriasis vulgaris phenotype.

objectivesThe objective of this study was to characterize the long-term outcomes of new-onset GP and elucidate the potential factors associated with a persistent disease course.

methodsThis was a retrospective cohort study. Patients diagnosed with new-onset GP between 2009 and 2020 with a follow-up period of at least 1 year, were enrolled. The examinees were evaluated by dermatologists. Detailed data retrieved from the examinees' medical files included demographics, disease characteristics, treatment, and comorbidities. A structured telephone questionnaire was used to determine the current psoriasis status: type, severity, and extent. At the end of follow-up, patients with a persistent disease course, defined as having lesions at least a year after disease onset, were compared with patients in complete remission without further psoriasis symptoms.

resultsA total of 120 patients (mean age 28.8 years [±15.2], 58.3% women) with new-onset GP flare were identified. At the end of follow-up period (mean 6.2 years [±3.1]), 49.1% (n = 59) of the patients reported active persistent psoriasis. A switch to the psoriasis vulgaris phenotype occurred in 17.5% (n = 21) of the study cohort. Persistent psoriasis was associated with male sex (OR = 2.1, p < 0.05), multiple disease flares (>3; OR = 9.1, p < 0.001), switch to the vulgaris phenotype (OR = 4.16, p < 0.001), and palmoplantar involvement (OR = 5.2, p < 0.01).

conclusionA persistent disease course is common among patients with new-onset GP, with most retaining their guttate phenotype throughout the disease course. Persistency was associated with male sex, multiple GP flares, switching to the vulgaris phenotype, and palmoplantar involvement.

Indexed as

PsoriasisComorbidityFemaleFollow-Up StudiesHumansMalePhenotypeRetrospective StudiesAutoimmune diseaseGuttate psoriasisPsoriasis vulgaris

Identifiers

PMID36481593
PMCPMC10015744
OpenAlexW4310959344

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.