Evidence map›Paper›PMID 36481457›Full record

ArticleGenomics, proteomics & bioinformatics2022

Genomic Shift in Population Dynamics of mcr-1-positive Escherichia coli in Human Carriage.

Yingbo Shen, Rong Zhang, Dongyan Shao, Lu Yang, Jiayue Lu, Congcong Liu, Xueyang Wang, Junyao Jiang, Boxuan Wang, Congming Wu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics, proteomics & bioinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Domestic travel as a driver for the dissemination ofAntimicrobial agents and chemotherapy · 2026
    Article
  2. Epidemiology, genetic dynamics, and transmission of theEmerging microbes & infections · 2025
    Article
  3. Article
  4. Global Variation inAntibiotics (Basel, Switzerland) · 2024
    Article
  5. Review
  6. Genome drafting of nosocomial infection CREFrontiers in cellular and infection microbiology · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yingbo ShenCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510641, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Rong ZhangThe Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310009, China.
Dongyan ShaoCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Lu YangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Jiayue LuThe Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310009, China.
Congcong LiuThe Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310009, China.
Xueyang WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Junyao JiangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Boxuan WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Congming WuCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510641, China.
Julian ParkhillDepartment of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.
Yang WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510641, China.
Timothy R WalshDepartment of Biology, University of Oxford, Oxford OX1 3SZ, UK. Electronic address: timothy.walsh@zoo.ox.ac.uk.
George F GaoCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Chinese Center for Disease Control and Prevention, Beijing 102206, China. Electronic address: gaof@im.ac.cn.
Zhangqi ShenCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510641, China. Electronic address: szq@cau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emergence of the colistin resistance gene, mcr-1, has attracted worldwide attention. Despite the prevalence of mcr-1-positive Escherichia coli (MCRPEC) strains in human carriage showing a significant decrease between 2016 and 2019, genetic differences in MCRPEC strains remain largely unknown. We therefore conducted a comparative genomic study on MCRPEC strains from fecal samples of healthy human subjects in 2016 and 2019. We identified three major differences in MCRPEC strains between these two time points. First, the insertion sequence ISApl1 was often deleted and the percentage of mcr-1-carrying IncI2 plasmids was increased in MCRPEC strains in 2019. Second, the antibiotic resistance genes (ARGs), aac(3)-IVa and bla

Indexed as

Escherichia coliEscherichia coli ProteinsAnti-Bacterial AgentsDrug Resistance, BacterialGenomicsHumansPlasmidsPopulation DynamicsAnti-Bacterial AgentsEscherichia coli ProteinsMCR-1 protein, E coliColistinEscherichia coliGenomicsHumanmcr-1

Identifiers

PMID36481457
PMCPMC10225485

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.