Evidence map›Paper›PMID 36481437›Full record

ReviewNeurobiology of disease2023

Brain edema formation and therapy after intracerebral hemorrhage.

Yingfeng Wan, Katherine G Holste, Ya Hua, Richard F Keep, Guohua Xi

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurobiology of disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07580235 (Clinical Study of Yiqi Huayu Jiedu Therapy in Non-Surgical Patients With Supratentorial Hypertensive Intracerebral Hemorrhage), which is not on this map. Cited by 102 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 3 pooled it
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07580235 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Clinical Study of Yiqi Huayu Jiedu Therapy in Non-Surgical Patients With Supratentorial Hypertensive Intracerebral Hemorrhage

TypeinterventionalSponsorGuangzhou University of Traditional Chinese MedicineRan2026 to 2030Enrolled902ConditionsIntracranial Hemorrhage, HypertensiveArmsYiqi Huayu Jiedu Mixture Intervention, The placebo
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 3 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. [Risk Nomogram Prediction Model for Cerebral Edema in Patients With Hypertensive Intracerebral Hemorrhage].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yingfeng WanDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Katherine G HolsteDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Ya HuaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address: rkeep@umich.edu.
Guohua XiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address: guohuaxi@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Experimental Cerebral Hemorrhage: Mechanisms and TherapiesR35NS116786 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2020 to 2024
$5.2M
Early hematoma lysis and hemoglobin toxicity in intracerebral hemorrhageR01NS106746 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEP, RICHARD F · 2018 to 2022
$2.5M
Targeting CD47 to aid in clearing intracerebral hemorrhagesR01NS096917 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA, XI, GUOHUA · 2016 to 2020
$1.7M
Peroxiredoxin-2 and Intracerebral Hemorrhage-Induced Brain InjuryR21NS112394 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA · 2019 to 2019
$429k
NINDS NIH HHS R01 NS096917NINDS NIH HHS R01 NS106746NINDS NIH HHS R21 NS112394NINDS NIH HHS R35 NS116786
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) accounts for about 10% of all strokes in the United States of America causing a high degree of disability and mortality. There is initial (primary) brain injury due to the mechanical disruption caused by the hematoma. There is then secondary injury, triggered by the initial injury but also the release of various clot-derived factors (e.g., thrombin and hemoglobin). ICH alters brain fluid homeostasis. Apart from the initial hematoma mass, ICH causes blood-brain barrier disruption and parenchymal cell swelling, which result in brain edema and intracranial hypertension affecting patient prognosis. Reducing brain edema is a critical part of post-ICH care. However, there are limited effective treatment methods for reducing perihematomal cerebral edema and intracranial pressure in ICH. This review discusses the mechanisms underlying perihematomal brain edema formation, the effects of sex and age, as well as how edema is resolved. It examines progress in pharmacotherapy, particularly focusing on drugs which have been or are currently being investigated in clinical trials.

Indexed as

Brain EdemaBrainCerebral HemorrhageHematomaHumansTreatment OutcomeBrain edemaIntracerebral hemorrhageMechanismsTherapy

Identifiers

PMID36481437
PMCPMC10013956
OpenAlexW4312083268

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.