Evidence map›Paper›PMID 36481106›Full record

ArticleVaccine2023

Added value of the measles-rubella supplementary immunization activity in reaching unvaccinated and under-vaccinated children, a cross-sectional study in five Indian districts, 2018-20.

C Prosperi, J W V Thangaraj, A Z Hasan, M S Kumar, S Truelove, V S Kumar, A K Winter, A K Bansal, S L Chauhan, G S Grover and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

C ProsperiInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
J W V ThangarajIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
A Z HasanInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
M S KumarIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
S TrueloveInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
V S KumarIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
A K WinterInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
A K BansalICMR-National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, India.
S L ChauhanICMR- National Institute for Research in Reproductive and Child Health (NIRRCH), Mumbai, India.
G S GroverDirectorate of Health Services, Government of Punjab, Chandigarh, India.
A K JainICMR-National Institute of Pathology, New Delhi, India.
R N KulkarniICMR- National Institute for Research in Reproductive and Child Health (NIRRCH), Mumbai, India.
S K SharmaICMR-Regional Medical Research Centre, NE Region, Dibrugarh, India.
B SomanAchutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
I K ChaaithanyaDepartment of Health Research, Model Rural Health Research Unit-Dahanu, Maharashtra, India.
S KharwalDepartment of Health Research, Model Rural Health Research Unit-Hoshiarpur, Punjab, India.
S K MishraDepartment of Health Research, Model Rural Health Research Unit-Hoshiarpur, Punjab, India.
N R SalviDepartment of Health Research, Model Rural Health Research Unit-Dahanu, Maharashtra, India.
N P SharmaDepartment of Health Research, Model Rural Health Research Unit-Chabua, Assam, India.
S SharmaDepartment of Health Research, Model Rural Health Research Unit-Kanpur, Uttar Pradesh, India.
A VargheseAchutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
R SabarinathanIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
A DuraiswamyIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
D S RaniIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
K KanagasabaiIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
A LachyanDepartment of Health Research, Model Rural Health Research Unit-Dahanu, Maharashtra, India.
P GawaliDepartment of Health Research, Model Rural Health Research Unit-Dahanu, Maharashtra, India.
M KapoorDepartment of Health Research, Model Rural Health Research Unit-Dahanu, Maharashtra, India.
S K ChonkerDepartment of Health Research, Model Rural Health Research Unit-Kanpur, Uttar Pradesh, India.
F T CuttsDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
L SangalWorld Health Organization, Southeast Asia Region Office, New Delhi, India.
S M MehendalePD Hinduja Hospital and Medical Research Centre, Mumbai, India.
G N SapkalICMR-National Institute of Virology, Pune, India.
N GuptaDivision of Epidemiology and Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
K HayfordInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
W J MossInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: wmoss1@jhu.edu.
M V MurhekarIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.

Funding

World Health Organization 001
6 · The paper itself

Abstract

introductionSupplementary immunization activities (SIAs) aim to interrupt measles transmission by reaching susceptible children, including children who have not received the recommended two routine doses of MCV before the SIA. However, both strategies may miss the same children if vaccine doses are highly correlated. How well SIAs reach children missed by routine immunization is a key metric in assessing the added value of SIAs.

methodsChildren aged 9 months to younger than 5 years were enrolled in cross-sectional household serosurveys conducted in five districts in India following the 2017-2019 measles-rubella (MR) SIA. History of measles containing vaccine (MCV) through routine services or SIA was obtained from documents and verbal recall. Receipt of a first or second MCV dose during the SIA was categorized as "added value" of the SIA in reaching un- and under-vaccinated children.

resultsA total of 1,675 children were enrolled in these post-SIA surveys. The percentage of children receiving a 1st or 2nd dose through the SIA ranged from 12.8% in Thiruvananthapuram District to 48.6% in Dibrugarh District. Although the number of zero-dose children prior to the SIA was small in most sites, the proportion reached by the SIA ranged from 45.8% in Thiruvananthapuram District to 94.9% in Dibrugarh District. Fewer than 7% of children remained measles zero-dose after the MR SIA (range: 1.1-6.4%) compared to up to 28% before the SIA (range: 7.3-28.1%). DISCUSSION: We demonstrated the MR SIA provided considerable added value in terms of measles vaccination coverage, although there was variability across districts due to differences in routine and SIA coverage, and which children were reached by the SIA. Metrics evaluating the added value of an SIA can help to inform the design of vaccination strategies to better reach zero-dose or undervaccinated children.

Indexed as

MeaslesRubellaChildCross-Sectional StudiesHumansImmunizationImmunization ProgramsInfantMeasles VaccineVaccinationMeasles VaccineCoverageMeaslesRoutine immunizationSupplementary immunization activitiesSurveys

Identifiers

PMID36481106
PMCPMC9831119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.