ReviewJournal of the American College of Cardiology2022
Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel.
Review in Journal of the American College of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 44 citations in OpenAlex.
- Myocardial late gadolinium enhancement is strongly associated with ventricular arrhythmias in mitral valve prolapse.The international journal of cardiovascular imaging · 2026Article
- Arrhythmic Mitral Valve Prolapse as a Regional Stretch-Induced Cardiomyopathy with Fibro-Inflammatory Signature: A Conceptual Review.Journal of cardiovascular development and disease · 2026Review
- Utility of genetic screening for the prediction of severe arrhythmic outcomes in mitral valve prolapse.medRxiv : the preprint server for health sciences · 2026Article
- Leveraging Self-Reporting in an Existing e-Cohort to Identify Clinically Relevant Mitral Valve Prolapse: Pilot Questionnaire Study.JMIR formative research · 2026Article
- Automated echocardiographic detection of mitral valve prolapse and mitral regurgitation with video-based artificial intelligence algorithms.European heart journal. Digital health · 2026Article
- Prevalence, Genetics, and Imaging Characteristics of Patients with Mitral Valve Prolapse and Arrhythmogenic Right Ventricular Cardiomyopathy.medRxiv : the preprint server for health sciences · 2026Article
- Mortality, Hospitalization, and Cardiac Interventions Among Patients With Mitral Valve Prolapse <65 Years of Age.Journal of the American Heart Association · 2026Article
- Automated Echocardiographic Detection of Mitral Valve Prolapse and Mitral Regurgitation with Video-based Artificial Intelligence Algorithms.medRxiv : the preprint server for health sciences · 2026Article
- The Arrhythmogenic Spectrum of Mitral Valve Disease: Pathophysiology, Risk Stratification, and Surgical Management.Journal of clinical medicine · 2026Review
- Role of 3D left ventricular end-systolic volume in risk stratification and outcome prediction in significant mitral regurgitation.European heart journal. Imaging methods and practice · 2026Article
- Floppy Mitral Valve/Mitral Valve Prolapse: Diagnosis and Clinical Classification in This Continuing Odyssey.European cardiology · 2026Review
- Phenotyping of Mitral Valve Prolapse Without Severe Mitral Regurgitation Using Electrocardiographic and Echocardiographic Data.JACC. Clinical electrophysiology · 2025Article
- Collagen Fiber Maturity and Architecture in MVP-Associated Fibrosis Quantified by Digital Pathology.Cells · 2025Article
- Is mitral annular disjunction the cause of arrhythmogenic mitral valve prolapse?European heart journal · 2025Article
- Multimodality Imaging of Arrhythmic Risk in Mitral Valve Prolapse.Circulation. Cardiovascular imaging · 2025Review
- Finding the Arrhythmic Needle in the Low-Risk Haystack: Heritability of Imaging Features of Arrhythmic Mitral Valve Prolapse.Circulation. Cardiovascular imaging · 2025Article
- Feasibility validation of automatic diagnosis of mitral valve prolapse from multi-view echocardiographic sequences based on deep neural network.European heart journal. Imaging methods and practice · 2024Article
- Impact of Sex on Severity Assessment and Cardiac Remodeling in Primary Mitral Regurgitation.JACC. Advances · 2024Article
- Primary Atriopathy in Mitral Valve Prolapse: Echocardiographic Evidence and Clinical Implications.Circulation. Cardiovascular imaging · 2024Article
- Noncomplex ventricular arrhythmia associated with greater freedom from recurrent ectopy at 1 year after mitral repair surgery.JTCVS open · 2024Article
Corrections and comments
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Authors and funding
20 authors at 15 institutions in 4 countries.
Funding
Abstract
In light of the adverse prognosis related to severe mitral regurgitation, heart failure, or sudden cardiac death in a subset of patients with mitral valve prolapse (MVP), identifying those at higher risk is key. For the first time in decades, researchers have the means to rapidly advance discovery in the field of MVP thanks to state-of-the-art imaging techniques, novel omics methodologies, and the potential for large-scale collaborations using web-based platforms. The National Heart, Lung, and Blood Institute recently initiated a webinar-based workshop to identify contemporary research opportunities in the treatment of MVP. This report summarizes 3 specific areas in the treatment of MVP that were the focus of the workshop: 1) improving management of degenerative mitral regurgitation and associated left ventricular systolic dysfunction; 2) preventing sudden cardiac death in MVP; and 3) understanding the mechanisms and progression of MVP through genetic studies and small and large animal models, with the potential of developing medical therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.