Evidence map›Paper›PMID 36480634›Full record

ArticleScience (New York, N.Y.)2022

Tuberculosis treatment failure associated with evolution of antibiotic resilience.

Qingyun Liu, Junhao Zhu, Charles L Dulberger, Sydney Stanley, Sean Wilson, Eun Seon Chung, Xin Wang, Peter Culviner, Yue J Liu, Nathan D Hicks and 7 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 2 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. MakingCell insight · 2026
    Review
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  18. mBio · 2026
    Article
  19. Variability in intrinsic drug tolerance inAntimicrobial agents and chemotherapy · 2025
    Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Qingyun Liu *Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-2284-5050
Junhao Zhu *Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-3301-5677
Charles L DulbergerDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-1334-5468
Sydney StanleyDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-6386-2415
Sean WilsonDepartment of Molecular and Cellular Biology, Harvard University, Boston, MA, USA.ORCID 0000-0002-7216-9804
Eun Seon ChungDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.ORCID 0000-0003-4947-4541
Xin WangDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-6930-3347
Peter CulvinerDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Yue J LiuDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-7785-857X
Nathan D HicksDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-6631-8383
Gregory H BabunovicDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-4158-6979
Samantha R GiffenDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Bree B AldridgeDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.ORCID 0000-0003-2236-1424
Ethan C GarnerDepartment of Molecular and Cellular Biology, Harvard University, Boston, MA, USA.ORCID 0000-0003-0141-3555
Eric J RubinDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-5120-962X
Michael C ChaoDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-3158-7337
Sarah M FortuneDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-7565-9975
Harvard University · USTufts University · USBroad Institute · US

Funding

Surviving evolution: Short-term adaptations for fitnessP01AI143575 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SABINE EHRT · 2020 to 2026
$18.2M
Gerome Wide Association Study of Bacterial Determinants of Clinical Response in TuberculosisU19AI142793 · NIAID · HARVARD MEDICAL SCHOOL · PI MURRAY, MEGAN B · 2019 to 2023
$14.6M
Systems Genetics of TuberculosisP01AI132130 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2017 to 2021
$11.2M
Single-cell factors of tuberculosis drug tolerance during adaptation to environmental stressorsR01AI143611 · NIAID · TUFTS UNIVERSITY BOSTON · PI ALDRIDGE, BREE BEARDSLEY · 2020 to 2023
$2.8M
NIAID NIH HHS P01 AI132130NIAID NIH HHS P01 AI143575NIAID NIH HHS R01 AI143611NIAID NIH HHS U19 AI142793
6 · The paper itself

Abstract

The widespread use of antibiotics has placed bacterial pathogens under intense pressure to evolve new survival mechanisms. Genomic analysis of 51,229

Indexed as

Antibiotics, AntitubercularBacterial ProteinsDrug Resistance, BacterialEvolution, MolecularMycobacterium tuberculosisTranscription FactorsTuberculosisTuberculosis, Multidrug-ResistantGenomicsHumansSelection, GeneticTreatment FailureAntibiotics, AntitubercularBacterial ProteinsTranscription Factors

Identifiers

PMID36480634
PMCPMC9968493
OpenAlexW4311887675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.