ArticleScience (New York, N.Y.)2022
Catalytic asymmetric C-H insertion reactions of vinyl carbocations.
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Catalytic Asymmetric Hydration of Alkenes.Journal of the American Chemical Society · 2026Article
- Unveiling mechanistic patterns of copper-catalyzed radical bond formation through linear free energy relationship.Nature communications · 2025Article
- Enantioselective dearomative single-atom skeletal editing of benzofurans.Nature communications · 2025Article
- Understanding and Enhancing Stereoselective Polymerization Using a Data Science Approach.Journal of the American Chemical Society · 2025Article
- Challenging the Bredt's rule in an acid catalyzed cationic cyclization to get bicyclo[3.3.1]nonane derivatives.Nature communications · 2025Article
- Divergent and Enantioselective Synthesis of Three Types of Chiral Polycyclic N‑Heterocycles via Copper-Catalyzed Dearomative Cyclization.ACS central science · 2025Article
- Stereoregular radical polymers enable selective spin transfer.Science advances · 2025Article
- Applying statistical modeling strategies to sparse datasets in synthetic chemistry.Science advances · 2025Review
- Article
- Asymmetric Büchner reaction and arene cyclopropanation via copper-catalyzed controllable cyclization of diynes.Nature communications · 2024Article
- Asymmetric one-carbon ring expansion of diverse N-heterocycles via copper-catalyzed diyne cyclization.Science advances · 2024Article
- Rh-Catalyzed Enantioselective Single-Carbon Insertion of Alkenes.Journal of the American Chemical Society · 2024Article
- Main Group-Catalyzed Cationic Claisen Rearrangements via Vinyl Carbocations.Organic letters · 2024Article
- Valence-isomer selective cycloaddition reaction of cycloheptatrienes-norcaradienes.Nature communications · 2024Article
- Enantioselective functionalization of unactivated C(spNature communications · 2024Article
- Accessing Medium-Sized Rings via Vinyl Carbocation Intermediates.Organic letters · 2024Article
- Article
- Inverse design of chiral functional films by a robotic AI-guided system.Nature communications · 2023Article
- Dual-Hydrogen-Bond Donor and Brønsted Acid Cocatalysis Enables Highly Enantioselective Protio-Semipinacol Rearrangement Reactions.Journal of the American Chemical Society · 2023Article
- α-Vinylation of Ester Equivalents via Main Group Catalysis for the Construction of Quaternary Centers.Organic letters · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
From the preparation of pharmaceuticals to enzymatic construction of natural products, carbocations are central to molecular synthesis. Although these reactive intermediates are engaged in stereoselective processes in nature, exerting enantiocontrol over carbocations with synthetic catalysts remains challenging. Many resonance-stabilized tricoordinated carbocations, such as iminium and oxocarbenium ions, have been applied in catalytic enantioselective reactions. However, their dicoordinated counterparts (aryl and vinyl carbocations) have not, despite their emerging utility in chemical synthesis. We report the discovery of a highly enantioselective vinyl carbocation carbon-hydrogen (C-H) insertion reaction enabled by imidodiphosphorimidate organocatalysts. Active site confinement featured in this catalyst class not only enables effective enantiocontrol but also expands the scope of vinyl cation C-H insertion chemistry, which broadens the utility of this transition metal-free C(sp
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.