Evidence map›Paper›PMID 36480614›Full record

ArticleScience (New York, N.Y.)2022

Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria.

Rohan Balakrishnan, Matteo Mori, Igor Segota, Zhongge Zhang, Ruedi Aebersold, Christina Ludwig, Terence Hwa

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed.

  1. Article
  2. Article
  3. Bridging bench and bedside: translational omics ofEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Bacterial stress responses lower mRNA-protein level correlations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Dynamic partitioning shapes thebioRxiv : the preprint server for biology · 2026
    Article
  9. mSystems · 2026
    Article
  10. Growth-dependent sensory bet-hedging enhances collective navigation.bioRxiv : the preprint server for biology · 2026
    Article
  11. Nocturnal hydration prepares desert cyanobacteria for dawn-light harvesting by inducing phycoerythrin synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Pleiotropic roles of elongation factor P inMicrobiology spectrum · 2026
    Article
  13. Article
  14. Very high CONAR genomics and bioinformatics · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rohan Balakrishnan *Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7547-8565
Matteo Mori *Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6263-8021
Igor SegotaDepartments of Medicine and Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8168-6144
Zhongge ZhangSection of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA.
Ruedi AebersoldFaculty of Science, University of Zurich, Zürich, Switzerland.ORCID 0000-0002-9576-3267
Christina LudwigBavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich (TUM), Freising, Germany.ORCID 0000-0002-6131-7322
Terence HwaDepartment of Physics, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-1837-6842

Funding

Quantitative Studies of Bacterial Growth PhysiologyR01GM095903 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HWA, TERENCE · 2011 to 2023
$3.8M
Quantitative Studies of Metabolic Switches in enteric bacteriaR01GM109069 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HWA, TERENCE · 2014 to 2022
$3.0M
NIGMS NIH HHS R01 GM095903NIGMS NIH HHS R01 GM109069
6 · The paper itself

Abstract

Protein concentrations are set by a complex interplay between gene-specific regulatory processes and systemic factors, including cell volume and shared gene expression machineries. Elucidating this interplay is crucial for discerning and designing gene regulatory systems. We quantitatively characterized gene-specific and systemic factors that affect transcription and translation genome-wide for

Indexed as

Escherichia coliGene Expression Regulation, BacterialProtein BiosynthesisRNA, MessengerDNA, BacterialPromoter Regions, GeneticRNA, BacterialTranscription, GeneticDNA, BacterialRNA, BacterialRNA, Messenger

Identifiers

PMID36480614
PMCPMC9804519

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.