Evidence map›Paper›PMID 36480601›Full record

ArticleScience (New York, N.Y.)2022

Coordinated control of neuronal differentiation and wiring by sustained transcription factors.

Mehmet Neset Özel, Claudia Skok Gibbs, Isabel Holguera, Mennah Soliman, Richard Bonneau, Claude Desplan

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Regulatory logic of neuronal differentiation in theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Temporal neuronal differentiation programs safeguard neuronal diversity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Single-cell transcriptomics of theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Regulatory logic of neuronal identity specification inbioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mehmet Neset ÖzelDepartment of Biology, New York University, New York, NY 10003, USA.ORCID 0000-0002-0185-5866
Claudia Skok GibbsFlatiron Institute, Center for Computational Biology, Simons Foundation, New York, NY 10010, USA.ORCID 0000-0002-6360-6128
Isabel HolgueraDepartment of Biology, New York University, New York, NY 10003, USA.ORCID 0000-0003-2796-6596
Mennah SolimanDepartment of Biology, New York University, New York, NY 10003, USA.ORCID 0000-0003-1724-0556
Richard BonneauDepartment of Biology, New York University, New York, NY 10003, USA.ORCID 0000-0003-4354-7906
Claude DesplanDepartment of Biology, New York University, New York, NY 10003, USA.ORCID 0000-0002-6914-1413
New York University · USSimons Foundation · USNew York University Abu Dhabi · AE

Funding

Center for Integrated Cellular Analysis - Valeria A. Sanchez EstradaRM1HG011014 · NHGRI · NEW YORK GENOME CENTER · PI LANDAU, DAN, SATIJA, RAHUL · 2020 to 2025
$22.1M
Stochastic choices in the retina and optic lobesR01EY013010 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2025
$9.1M
Neurogenesis of the optic lobesR01EY017916 · NEI · NEW YORK UNIVERSITY · PI Claude Desplan · 2007 to 2026
$8.0M
Modeling Gene Regulatory Networks for Early Cardiopharyngeal DevelopmentR01HD096770 · NICHD · NEW YORK UNIVERSITY · PI BONNEAU, RICHARD A, CHRISTIAEN, LIONEL · 2018 to 2022
$3.0M
The biochemical, topological and functional impact of cancer associated Ctcf mutations and their contribution to cancerR01CA229235 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SKOK, JANE AMANDA · 2018 to 2018
$482k
Gene Regulatory Networks of Synaptic SpecificityK99NS125117 · NINDS · NEW YORK UNIVERSITY · PI OZEL, MEHMET NESET · 2022 to 2023
$254k
NCI NIH HHS R01 CA229235NEI NIH HHS R01 EY013010NEI NIH HHS R01 EY017916NHGRI NIH HHS RM1 HG011014NICHD NIH HHS R01 HD096770NINDS NIH HHS K99 NS125117
6 · The paper itself

Abstract

The large diversity of cell types in nervous systems presents a challenge in identifying the genetic mechanisms that encode it. Here, we report that nearly 200 distinct neurons in the

Indexed as

Drosophila melanogasterDrosophila ProteinsNeural Stem CellsNeurogenesisNeuronsOptic Lobe, NonmammalianTranscription FactorsAnimalsGene Expression Regulation, DevelopmentalDrosophila ProteinsTranscription Factors

Identifiers

PMID36480601
PMCPMC10193265
OpenAlexW4310963914

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.