ArticleCNS neuroscience & therapeutics2023
Altered neurovascular coupling in children with idiopathic generalized epilepsy.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Individual 18F-FDG PET and arterial spin labeling coupling based on simultaneous PET/MRI predicting anti-seizure medication response in temporal lobe epilepsy patients.European journal of nuclear medicine and molecular imaging · 2026Article
- Alterations of multilayer network correlated with cognitive impairment and gene expression profiles in children with idiopathic generalized epilepsy.Scientific reports · 2025Article
- Altered coupling of cerebral blood perfusion and neuronal activity in children with MRI-negative drug refractory epilepsy.Quantitative imaging in medicine and surgery · 2025Article
- Dissociation of Structural and Functional Connectivity and Metabolism in the Neocortex of Idiopathic Generalized Epilepsy: A Simultaneous PET/MRI Multimodal Study.AJNR. American journal of neuroradiology · 2025Article
- SimultaneousNeuroradiology · 2025Article
- Review
- [Brain Dynamic Functional Connectivity in Children and Adolescents With Conventional MRI-Negative Idiopathic Generalized Epilepsy].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis.Brain communications · 2024Article
- Resting-state functional MRI study of conventional MRI-negative intractable epilepsy in children.Frontiers in human neuroscience · 2024Article
- Altered neurovascular coupling in children with idiopathic generalized epilepsy.CNS neuroscience & therapeutics · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAlterations in neuronal activity and cerebral hemodynamics have been reported in idiopathic generalized epilepsy (IGE) patients, possibly resulting in neurovascular decoupling; however, no neuroimaging evidence confirmed this disruption. This study aimed to investigate the possible presence of neurovascular decoupling and its clinical implications in childhood IGE using resting-state fMRI and arterial spin labeling imaging.
methodsIGE patients and healthy participants underwent resting-state fMRI and arterial spin labeling imaging to calculate degree centrality (DC) and cerebral blood flow (CBF), respectively. Across-voxel CBF-DC correlations were analyzed to evaluate the neurovascular coupling within the whole gray matter, and the regional coupling of brain region was assessed with the CBF/DC ratio.
resultsThe study included 26 children with IGE and 35 sex- and age-matched healthy controls (HCs). Compared with the HCs, the IGE group presented lower across-voxel CBF-DC correlations, higher CBF/DC ratio in the right posterior cingulate cortex/precuneus, middle frontal gyrus, and medial frontal gyrus (MFG), and lower ratio in the left inferior frontal gyrus. The increased CBF/DC ratio in the right MFG was correlated with lower performance intelligence quotient scores in the IGE group.
conclusionChildren with IGE present altered neurovascular coupling, associated with lower performance intelligence quotient scores. The study shed a new insight into the pathophysiology of epilepsy and provided potential imaging biomarkers of cognitive performances in children with IGE.
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