Evidence map›Paper›PMID 36480390›Full record

Trial reportExperimental and clinical psychopharmacology2023

Polygenic risk for alcohol consumption and multisite chronic pain: Associations with ad lib drinking behavior.

Kyle M White, Jonathan L Hess, Stephen J Glatt, Stephen A Maisto, Michael J Zvolensky, Joseph W Ditre

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Experimental and clinical psychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kyle M WhiteDepartment of Psychology, Syracuse University.ORCID 0000-0001-5781-3780
Jonathan L HessDepartment of Psychiatry and Behavioral Sciences, State University of New York, Upstate Medical University.
Stephen J GlattDepartment of Psychiatry and Behavioral Sciences, State University of New York, Upstate Medical University.
Stephen A MaistoDepartment of Psychology, Syracuse University.
Michael J ZvolenskyDepartment of Psychology, University of Houston.
Joseph W DitreDepartment of Psychology, Syracuse University.ORCID 0000-0002-8914-6908
Syracuse University · USSUNY Upstate Medical University · USUniversity of Houston · US

Funding

Testing a Digital Therapeutic for Smoking Cessation among Hispanic Persons who SmokeU54MD015946 · NIMHD · UNIVERSITY OF HOUSTON · PI Stacey Lynn Gorniak · 2020 to 2026
$22.0M
The Alcohol-Pain Connection: Mechanisms and Genetic/Psychological CorrelatesR01AA024844 · NIAAA · SYRACUSE UNIVERSITY · PI DITRE, JOSEPH W., MAISTO, STEPHEN A · 2016 to 2020
$2.0M
Personalized feedback intervention to address hazardous drinking and alcohol-opioid interactions among adults with chronic painR01AA028639 · NIAAA · SYRACUSE UNIVERSITY · PI DITRE, JOSEPH W., ZVOLENSKY, MICHAEL J. · 2020 to 2023
$1.3M
Integrating Genetic, Neuroimaging, Transcriptomic, and Clinical Risk Factors as Multivariate Predictors of Cognitive Deterioration in Alzheimer's Disease.R01NS128535 · NINDS · UPSTATE MEDICAL UNIVERSITY · PI HESS, JONATHAN · 2022 to 2024
$1.2M
Profiling the Functional Genetics of Health and Disease using BrainGENIE: The Brain Gene Expression and Network Imputation EngineR21MH126494 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI GLATT, STEPHEN J, HESS, JONATHAN · 2021 to 2022
$446k
NIAAA NIH HHS R01 AA024844NIAAA NIH HHS R01 AA028639NIMHD NIH HHS U54 MD015946NIMH NIH HHS R21 MH126494NINDS NIH HHS R01 NS128535
6 · The paper itself

Abstract

Interrelations between alcohol use disorder and chronic pain have received increasing empirical attention, and several lines of evidence support the possibility of shared genetic liability. However, research on the genetic contributions to the component processes of these complex and potentially overlapping phenotypes remains scarce. The goal of the present study was to test polygenic risk scores (PRSs) for alcohol consumption and multisite chronic pain as predictors of ad lib drinking behavior during an experimental taste test. PRSs were calculated for 209 pain-free, moderate-to-heavy drinkers (57.9% male; 63.6% White). Among White participants, the alcohol and chronic pain PRSs showed nominally significant (

Indexed as

AlcoholismChronic PainAlcohol DrinkingBlood Alcohol ContentEthanolFemaleHumansMaleRisk FactorsBlood Alcohol ContentEthanol

Identifiers

PMID36480390
PMCPMC10247901
OpenAlexW4310946615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.