Evidence map›Paper›PMID 36480131›Full record

ReviewClinical and experimental pharmacology & physiology2023

Therapeutic potential of curcumin in ARDS and COVID-19.

Madathilparambil V Suresh, Sairah Francis, Sinan Aktay, Georgia Kralovich, Krishnan Raghavendran

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and experimental pharmacology & physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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  13. Therapeutic potential of curcumin in ARDS and COVID-19.Clinical and experimental pharmacology & physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Madathilparambil V SureshDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Sairah FrancisDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Sinan AktayDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Georgia KralovichDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Krishnan RaghavendranDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan–Ann Arbor · US

Funding

Mechanisms of MCP-1 in lung contusion with and without gastric aspirationR01HL102013 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGHAVENDRAN, KRISHNAN · 2010 to 2013
$1.5M
Regulation of Hypoxia Inducible Factor -1α in Alveolar Epithelial Cells in Lung ContusionR01GM111305 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGHAVENDRAN, KRISHNAN · 2015 to 2018
$1.3M
NHLBI NIH HHS R01 HL102013NIGMS NIH HHS R01 GM111305
6 · The paper itself

Abstract

Curcumin is a safe, non-toxic, readily available and naturally occurring compound, an active constituent of Curcuma longa (turmeric). Curcumin could potentially treat diseases, but faces poor physicochemical and pharmacological characteristics. To overcome these limitations, we developed a stable, water-soluble formulation of curcumin called cyclodextrin-complexed curcumin (CDC). We have previously shown that direct delivery of CDC to the lung following lipopolysaccharides exposure reduces acute lung injury (ALI) and effectively reduces lung injury, inflammation and mortality in mice following Klebsiella pneumoniae. Recently, we found that administration of CDC led to a significant reduction in angiotensin-converting enzyme 2 and signal transducer and activator of transcription 3 expression in gene and protein levels following pneumonia, indicating its potential in treating coronavirus disease 2019 (COVID-19). In this review, we consider the clinical features of ALI and acute respiratory distress syndrome (ARDS) and the role of curcumin in modulating the pathogenesis of bacterial/viral-induced ARDS and COVID-19.

Indexed as

Acute Lung InjuryCOVID-19CurcuminRespiratory Distress SyndromeAnimalsLungMiceCurcuminALIARDSCOVID-19curcuminNF-κBpneumonia

Identifiers

PMID36480131
PMCPMC9877870
OpenAlexW4310963014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.